--- Content provided by FirstRanker.com ---(FEBRUARY 2021 EXAM SESSION)
B. PHARMACY DEGREE EXAMINATION
FOURTH (FINAL) YEAR ? (NON-SEMESTER)
PAPER IV ? MODERN METHODS OF PHARMACEUTICAL ANALYSIS
Time: Three hours
Answer ALL questions Maximum: 100 Marks
(2 x 20 = 40)
1. Explain in detail the method development and validation parameters in HPLC.
2. a) Explain the principle and instrumentation of gas chromatography.
b) What are the different types of detectors used in gas chromatography?
II. Write notes on:
(8 x 5 = 40)
1. Draw and label a typical polarogram showing the dif
2. Draw the proton NMR spectrum of 1-Bromopropane indicating the number of signals,
3. In mass spectrometry what is matrix assisted laser desorption ionization? Explain.
4. Outline the principle of Radio Immuno Assay.
5. Briefly explain the different types of Conductometric titrations.
6. Explain "Dead stop End Point" titration.
8. Briefly explain the calibration of UV Spectrophotom
III. Short answers on:
(10 x 2 = 20)
2. In mass spectrometry what is metastable ion peak?
3. In polarography what causes a maxima. How is it eliminated?
4. How will you calculate the vibrational degrees of freedom for a linear molecule and
non linear molecules.
6. Distinguish between equivalent and molar conductance.
7. State Bragg's law.
8. Distinguish between Quality Assurance and Quality Control.
9. What is Reverse Phase Chromatography?
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B. PHARMACY DEGREE EXAMINATION
--- Content provided by FirstRanker.com ---
FOURTH (FINAL) YEAR ? (NON-SEMESTER)
PAPER IV ? MODERN METHODS OF PHARMACEUTICAL ANALYSIS
--- Content provided by FirstRanker.com ---
Q.P. Code: 564270Time: Three hours
--- Content provided by FirstRanker.com ---
Answer ALL questions Maximum: 100 Marks
--- Content provided by FirstRanker.com ---
I. Elaborate on:(2 x 20 = 40)
1. Explain in detail the method development and validation parameters in HPLC.
--- Content provided by FirstRanker.com ---
2. a) Explain the principle and instrumentation of gas chromatography.
b) What are the different types of detectors used in gas chromatography?
--- Content provided by FirstRanker.com ---
II. Write notes on:
(8 x 5 = 40)
--- Content provided by FirstRanker.com ---
1. Draw and label a typical polarogram showing the dif
2. Draw the proton NMR spectrum of 1-Bromopropane indicating the number of signals,
--- Content provided by FirstRanker.com ---
their relative positions and splitting pattern.3. In mass spectrometry what is matrix assisted laser desorption ionization? Explain.
4. Outline the principle of Radio Immuno Assay.
--- Content provided by FirstRanker.com ---
5. Briefly explain the different types of Conductometric titrations.
6. Explain "Dead stop End Point" titration.
--- Content provided by FirstRanker.com ---
7. What is the principle behind IR spectroscopy.8. Briefly explain the calibration of UV Spectrophotom
--- Content provided by FirstRanker.com ---
III. Short answers on:
(10 x 2 = 20)
--- Content provided by FirstRanker.com ---
1. Mention the two differences in the instrumentation of a UV spectrophometer and a2. In mass spectrometry what is metastable ion peak?
3. In polarography what causes a maxima. How is it eliminated?
--- Content provided by FirstRanker.com ---
4. How will you calculate the vibrational degrees of freedom for a linear molecule and
non linear molecules.
--- Content provided by FirstRanker.com ---
5. Mention the different types of qualification are equipment validation.6. Distinguish between equivalent and molar conductance.
7. State Bragg's law.
--- Content provided by FirstRanker.com ---
8. Distinguish between Quality Assurance and Quality Control.
9. What is Reverse Phase Chromatography?
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10. What is the principle behind the electrophoresis?*******