Download HNGU MBBS 1st Year Biochemistry Dec 2013 Question Paper

Date: 05-12-2013
Instructions:
1. Answer to the points. 2. Figure to the right
indicates marks. 3. Use separate answer books
for each section. 4. Draw diagrams wherever

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necessary. 5. Write legibly.
Section 1
1.Write short notes on: (any two)
a. PCR, technique its advantages and medical
application

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b. Blotting techniques and its application
c. Recombinant DNA technology
(10)
2.Write Short notes on (any three)
a. Replication of DNA

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b. Salient features of genetic code
c. Post translational modifications of proteins
d. DNA repair mechanism
e. Mutations
(9)

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3.Write Short notes on (any two)

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a. Balanced Diet
b. Protein energy malnutrition (PEM)
c. Metabolic adaptations during prolonged
starvation

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(6)
Section 2
4.Write Short notes on (any two)
a. Formation of ammonia and its fate
b. Function and regulation of serum calcium

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c. Plasma proteins and their clinical significance
(10)
5.Write Short notes on (any three) out of five)
a. Role of B-complex vitamins as coenzymes
b. One carbon metabolism

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c. Role of PRPP in salvage pathway
d. Hyperuricemia and Gout
e. Folic acid
(9)
6.Read the case report and answer the

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following questions. A 60 yr old male presented
with epigastric pain radiating to back for 3
months. Weight loss for threee months, dark

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urine and clay cloured stool for one
week.leterus present on investigation: Scrum

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bilirubin Patient report Normal value Total 12
mg/dl 0.4-4 mg/dl Direct 15 mg/dl 0.1-0.4 mg/dl
Indirect 0.5 mg/dl 0.22-0.7 mg/dl Urine bilirubin
Positive Negative Serum ALT, AST and alkaline
phosphate report awaited. Radiologucal

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investigations revealed presence of tumor in
head pf pancreas and dilated biliary canaliculi
and duct.
a. What kind of Jaundice from?
b. What do you understand by direct and

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indirect bilirubin?
c. What is Van den Bergh reaction and what is
its significance in differential diagnosis of
Jaundice?
d. Will bile salt be present in urine of this

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patient?
e. Which test can be performed to detect the
presence of bile salts in urine?
f. What will be the status of serum of, serum
AST ALT and alkaline phosphate in this

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patient?
(6)
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