GV 3006
First Year MBBS Examination
I MBBS Biochemistry Paper 2
Time: 3 hours
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Max Marks: 50Instructions: 1. Answer to the points. 2. Figure to the right
indicates marks. 3. Use separate answer books for each
section. 4. Draw diagrams wherever necessary. 5. Write
legibly.
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Section 11. Give an account of: (any two) (10)
a. Causes and deficiency manifestations of folic acid (A. 475)
(C. 151)
b. Phenylketonuria (A. 292) (C. 351)
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c. Gene Therapy (A. 604) (C.625)2. Write Short notes on (any three) (9)
a. Telomere and functions of telomerase
b. Post-translational modifications and inhibitors of
translation (A. 572) (C. 547)
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c. Southern blot technique and its application (A. 609) (C.382)
d. Vectors used in Re-combinant DNA technology (A. 600)
(C. 579)
e. Phase I reactions of Detoxication mechanism
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3. Write Short notes on (any tw0) (6)a. Balanced diet (B. 761) (C.514)
b. Metabolism in starvation (A. 122) (. 383)
c. Protein energy malnutrition
Section 2
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1. Give an account on (any two) (10)a. Ammonia formation transportation excretion disorders and
toxicity
b. Sources absorption function and disorders of Iran in body
c. Functions of amino acid glycine and sulphur containing
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amino acids (A. 275) (C.361)2. Write Short notes on (any three) (9)
a. Folate trap (A. 478) (C.156)
b. High energy compounds
c. Vitamin K (A. 461) (C.130)
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d. Salvage pathway (A. 546) (C. 391)e. Acute phase proteins
3. Write Short notes of (any six): A 45 year old businessman
after attending New Year party with food and alcohol
returned lately in the night. Next day morning he was (6)
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awaken from sleep with severe pain in his Big toe. Licattended OPD and examination the 1st metatarsal joint was
tender and inflamed. in investigation the findings were as
follows. Scrum Uric acid 9 mg% (normal 4-7 mg%) Scrum
Cholesterol 200 mg% (Normal 15Q-220 mg%) Fasting Blood
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Glucose 110 mg% (Normal 90-110 mg%) On clinicalexamination the 1st metatarsal joint was tender and
inflamed.
a. The case was diagnosed as GOUT
b. What is Gout? (A. 548) (C. 394)
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c. What are the causes of primary Gout?d. What is relation between consumption of meaty food and
Gout?
e. What is relation between alcohol consumption and
precipitation og Gouty arthritis?
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f. Why are the causes of secondary Gout?
g. How the drug Allopurinal works in treatment of Gout?
h. Why gouty arthritis is seen in peripheral joints?
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