C 2745
First Year MBBS Examination
I MBBS Biochemistry Paper 1
Time: 3 hours Date: 10-10-2019 Max Marks: 50
Instructions:
2. Figure to the right indicates marks.
3. Use separate answer books for each section.
4. Draw diagrams wherever necessary.
5. Write legibly.
1. Give an account on any two: (10)
a. Metabolism of HDL and add a note on
Frederickson's classification of hyperlipidemia.
b. Diagnostically and therapeutically important
c. Role of renal system in regulation of plasma pH
and state the reference range of plasma pH.
Add a note on Anion Gap.
2. Write short notes on any three (9)
b. Thyroid function tests.
c. Role of renin-angiotensin aldosterone in
maintenance of water balance,
d. Role of Debranching enzyme, Add a note on
e. Air pollution,
3. Read the following case and answer the below
mentiioned related questions: 12 year old African
boy was brought to the hospital by his parents
pain.He does report feeling tired and fatigued
easily on mild work. On examination his
conjunctiva and mucosal membranes are slightly
yellowish. Laboratory raveatigations revealed
11-13 gm/dl) Total Bilirubin 2.2 mg/dl(Normal
0.2-1.0 mg/dl) Indirect Bilirubin 2.2
mg/dl(Normal 0.2-0.8 mg/dl) Direct Bilirubin 0.2
mg (Normal 0-0.2 mg/dl) Hematocrit 22%
cell disease.
a. Othe than the blood smear examinationwhich
test help in the diagnosis of the sickle cell
condition? What treatment policies to be
b. What is the molecular defect in sickle cell
c. What is sickle cell trait condition?
d. Why patient was getting easily fatigued?
e. What is sickle cell crisis?
f. State the reason behind yellowish coloration of
conjunctiva and mucosal membranes.
Section 2
1. Give an account on any two: (10)
a. State the differences between competitive &
useful competitive inhibitors.
b. Guconeogenesis and its importance.
c. Reactive oxygen species-its generation in living
cells & effect on human health Add a note on
2. Write short notes on any three (9)
a. Tumor Markers
b. Fatty liver.
c. Metabolism of alcohol. Add a note on
alterations in alcoholism.
d. Ion channels-its role in transport of substances
across cell membrane.
e. Principle and applications of Radioimmun
3. Comment and justify on any six of the following
(6)
a. Viper bite causes severe hemolysis.
b. Lactulose is useful in the treatment of hepatic
c. Aspirin is used as an anti-inflammatory drug.
d. In obstructive jaundice, feces are clay colored
but urine is darker in colour.
e. Recurrent pyogenic infection by staphylococci
f. Lipoprotein (a) is strongly associated with
myocardial infarction.
g. Glucose is administered to relieve an attack of
acute intermittent porphyria.
organophosphorus poisoning.
***
First Year MBBS Examination
I MBBS Biochemistry Paper 1
Time: 3 hours Date: 10-10-2019 Max Marks: 50
Instructions:
--- Content provided by FirstRanker.com ---
1. Answer to the points.2. Figure to the right indicates marks.
3. Use separate answer books for each section.
4. Draw diagrams wherever necessary.
5. Write legibly.
--- Content provided by FirstRanker.com ---
Section 11. Give an account on any two: (10)
a. Metabolism of HDL and add a note on
Frederickson's classification of hyperlipidemia.
b. Diagnostically and therapeutically important
--- Content provided by FirstRanker.com ---
enzymes,c. Role of renal system in regulation of plasma pH
and state the reference range of plasma pH.
Add a note on Anion Gap.
2. Write short notes on any three (9)
--- Content provided by FirstRanker.com ---
a. Oxidative phosphorylation and its inhibitors.b. Thyroid function tests.
c. Role of renin-angiotensin aldosterone in
maintenance of water balance,
d. Role of Debranching enzyme, Add a note on
--- Content provided by FirstRanker.com ---
Von-Gierke's disease,e. Air pollution,
3. Read the following case and answer the below
mentiioned related questions: 12 year old African
boy was brought to the hospital by his parents
--- Content provided by FirstRanker.com ---
with complaints of (6) recurrent joint and bonepain.He does report feeling tired and fatigued
easily on mild work. On examination his
conjunctiva and mucosal membranes are slightly
yellowish. Laboratory raveatigations revealed
--- Content provided by FirstRanker.com ---
following results :Hemoglobin 7.1 g/dl(Normal11-13 gm/dl) Total Bilirubin 2.2 mg/dl(Normal
0.2-1.0 mg/dl) Indirect Bilirubin 2.2
mg/dl(Normal 0.2-0.8 mg/dl) Direct Bilirubin 0.2
mg (Normal 0-0.2 mg/dl) Hematocrit 22%
--- Content provided by FirstRanker.com ---
(Normal 40-54%) He was diagnosed with Sicklecell disease.
a. Othe than the blood smear examinationwhich
test help in the diagnosis of the sickle cell
condition? What treatment policies to be
--- Content provided by FirstRanker.com ---
advised to this patient?b. What is the molecular defect in sickle cell
c. What is sickle cell trait condition?
d. Why patient was getting easily fatigued?
e. What is sickle cell crisis?
--- Content provided by FirstRanker.com ---
f. State the reason behind yellowish coloration of
conjunctiva and mucosal membranes.
Section 2
1. Give an account on any two: (10)
a. State the differences between competitive &
--- Content provided by FirstRanker.com ---
non-competitive inhibition. Add a note onuseful competitive inhibitors.
b. Guconeogenesis and its importance.
c. Reactive oxygen species-its generation in living
cells & effect on human health Add a note on
--- Content provided by FirstRanker.com ---
lipid peroxidation.2. Write short notes on any three (9)
a. Tumor Markers
b. Fatty liver.
c. Metabolism of alcohol. Add a note on
--- Content provided by FirstRanker.com ---
labolatory findings and biochemical alterationsalterations in alcoholism.
d. Ion channels-its role in transport of substances
across cell membrane.
e. Principle and applications of Radioimmun
--- Content provided by FirstRanker.com ---
Assay (RIA)3. Comment and justify on any six of the following
(6)
a. Viper bite causes severe hemolysis.
b. Lactulose is useful in the treatment of hepatic
--- Content provided by FirstRanker.com ---
encephalopathy.c. Aspirin is used as an anti-inflammatory drug.
d. In obstructive jaundice, feces are clay colored
but urine is darker in colour.
e. Recurrent pyogenic infection by staphylococci
--- Content provided by FirstRanker.com ---
are common in chronic granulomatous disease.f. Lipoprotein (a) is strongly associated with
myocardial infarction.
g. Glucose is administered to relieve an attack of
acute intermittent porphyria.
--- Content provided by FirstRanker.com ---
h. Cholinesterase enzyme activity decreases inorganophosphorus poisoning.
***