MK 16805
First Year MBBS Examination
I MBBS Biochemistry Paper 1
Time: 3 hours Max Marks: 50
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Instructions: 1. Answer to the points. 2. Figureto the right indicates marks. 3. Use separate
answer books for each section. 4. Draw
diagrams wherever necessary. 5. Write legibly.
Section 1
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1. Give an account of: (any two) (10)a. Diabetes Mellitus types, metabolic
arrangements, clinical symptoms and its
associated complications
b. Cardiac Biomarkers
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c. Hemoglobinopathies2. Write Short notes on (any three) (9)
a. Mucopolysaccharides and its associated
disorders (A. 98) (C.22)
b. Biological action and clinical applications
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of Prostaglandins (A. 243) (C.644)c. Isoenzymes of Alkaline Phosphate and
their clinical significance
d. Competitive inhibition and state how it
differs from Non-competitive inhibition (A.
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63) (C.92)e. Unconjugated hyperbilirubinemia
3. Write Short notes on (any two) (6)
a. Metabolic acidosis (A. 402) (C.481)
b. Role of rennin-angiotensin-aldosterone
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system in regulation of water balancec. Renal function test (A. 370) (C. 459)
Section 2
4. Give an account on (any two) (10)
a. Ketone bodies metabolism
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b. HMP shunt pathway and its significance(A. 144) (C. 270)
c. Regulation of blood glucose and state the
reference range of plasma glucose
5. Write Short notes of (any three) (9)
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a. Proto-oncogenes and mechanism ofactivation of proto-oncogenes to
oncogenes
b. Air pollution (A. 534) (C.663)
c. Structural organization of Electron
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transport chain and inhibition of oxidativephosphorylation (A. 315, 318) (C. 226,
232)
d. Antioxidant enzymes (A. 426) (C.658)
e. Principles and applications of
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chromatography (A. 434) (C.719)6. Write Short notes on (any three) (6)
a. Cholinesterase enzyme activity decreases
in organ phosphorous poisoning
b. Glucose is administered to relieve an
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attack of acute intermittent porphyriac. Enzymes are used as therapeutic agents
d. Lipoprotein (is strongly associated with
myocardial infarction
e. Lactulose is used for the treatment of
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haptic encephalopathyf. In obstructive jaundice stools are clay
coloured and urine is dark yellow
g. Viper bites causes severe hemolysis
h. Excessive alcohol consumption lead to
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fatty liver***