First Year MBBS Examination
I MBBS Biochemistry Paper 1
Time: 3 hours
Max Marks: 50
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Instructions: 1. Answer to the points. 2. Figureto the right indicates marks. 3. Use separate
answer books for each section. 4. Draw
diagrams wherever necessary. 5. Write legibly.
Section 1
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1.Give an account of: (any two) (10)a. Name the important blood buffers and
describe the role of kidney and lungs in
maintenance of acid base balance. (A. 398)
(C. 475)
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b. Lipoproteins (A. 217) (C. 317)c. Hyperbilirubinemia (A. 330) (C. 214)
2.Write Short notes on (any three) (9)
a. Diagnostic importance of enzyme assay
b. Factors affecting enzyme action (A. 60) (C.
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88)c. Mucopolysaccharides (A. 98) (C. 22)
d. Trans Fatty acids
e. Sphingolipids
3.Write Short notes on (any two) (6)
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a. Active transport (A. 15) (C. 651)b. ELISA (A. 437) (C.729)
c. Thyroid function test (A. 637) (C.465)
Section 2
4.Give an account on (any two) (10)
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a. Krebs Cycle and its energeticb. Metabolism of ketone bodies
c. Regulation of cholesterol Biosynthesis
5.Write Short notes on (any three) (9)
a. Oxidative Phosphorylation (A. 318) (C.228)
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b. Laboratory Diagnosis of Diabetes mellitusc. Lead toxicity (A. 532) (C.666)
d. Tumour markers (A. 666) (C.691)
e. Immunoglobulin structure and functions (A.
649) (C.186)
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6.Write Short notes of (any six) (6)a. HDL cholesterol is good cholesterol
b. Biochemical basis of cyanide poisoning
c. Essential Fatty acids prevents fatty liver
d. P53 is the guardian of the gemone
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e. Dietary fibers prevents hypercholesterolemiaf. High estrogen are associated with reduced
breast cancer risks
g. Fasting hypoglycemia is observed in Von
Gierke's disease
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h. Monoclonal antibodies are preferred thanpolyclonal antibodies for diagnosis and
therapeutics.
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