Date: 11-02-2015
I MBBS Biochemistry Paper 1
Time: 3 hours
Max Marks: 50
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Instructions: 1. Answer to the points. 2. Figure tothe right indicates marks. 3. Use separate answer
books for each section. 4. Draw diagrams wherever
necessary. 5. Write legibly.
Section 1
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1. Write Short notes on (any two) (6)a. Protein energy malnutrition (PEM)
b. BMR
c. Metabolic adaptation during starvation
Section 2
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4. Write Short notes on (any two) (10)a. Physiologically important substances
synthesized from tyrosine
b. Copper metabolism
c. Inhibitors of translation
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5. Write Short notes on (any three) out of five) (9)a. Disorders of Pyrimidine metabolism
b. Purine salvage pathway
c. Biologically important nucleotides
d. Protein structure
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e. Vitamin A and visual cycle6. Write Justification of following statements: (any
six) :One evening, a smart 40 years old male
business executive entertained 3 party in which
much food and alcohol (6) had been consumed. In
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the next carly morning, he woke: Up withexcruciating pain in ankle. He was admitted in the
hospital, on examination, he had fever, his ankle
joint was swallow and red felt hot to touch.
Routine peripheral smear revealed mild
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granulocytosis. The laboratory data were Bloodglucose 130 mg/dl. Blood Urca 38 mg/dl: Serum
creatinine: 1 mg/dl; Scrum Uric acid: 10 mg/dl:
Urine PH was found to be 2
a. What is the most probable diagnosis?
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b. Why in lactic acidosis secondary gout occurs?c. What is HGPRT?
d. What are the causes for primary hyperuricemia?
e. What are the causes for secondary
hyperuricemia?
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f. Why patients with Von Gierkee's disease havehyperuricemia?
g. Which type of food will precipitate an attack of
gout?
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