C 2746
First Year MBBS Examination
I MBBS Biochemistry Paper 2
Time: 3 hours
Max Marks: 50
Instructions: 1. Answer to the points. 2. Figure
to the right indicates marks. 3. Use separate
answer books for each section. 4. Draw
diagrams wherever necessary. 5. Write legibly.
1. Give an account on any two (10)
a. Causes and deficiency manifestations of
Vitamin B12.
b. Repair mechanism of damaged DNA and
c. Recombinant DNA Technology and its
applications.
2. Write Short Note on any three (9)
a. Phase I reactions of detoxification
mechanism.
b. Use of Radio-isotopes in Medicine.
c. Gene Therapy.
d. Plasma proteins as diagnostic tools.
e. Lac operon.
three lines: A 65 years old man presented
With back pain, loss of weight and
breathlessness. On examination he was (6)
anaemic. Investigations showed:Hb
proteins:10.5gm/dL,albumin 3 gm/dl.scrum
urca 48 gm/dl, serum Creatinine 2.4mg/dL
serum protein electrophoresis showed M
band in gamma region. In urine, Bence
examination showed punched out lytic
lesions in lumbar vertebrae, ribs, pelvis
vertebrae, ribs and pelvis.
a. What is the likely diagnosis?
G ratio is reversed.
c. What are Bence Jones Proteins?
d. What is the normal pattern of serum
proteins in electrophoresis?
different from normal immunoglobulin
molecule?
f. How Bence Jones Proteins are detected in
urine?
1. Give an account on any two: (10)
a. Protein Energy Malnutrition (PEM).
b. Sources, absorption, transport, functions
and disorders of Calcium,
2. Write Short Note on any three (9)
a. Salvage pathway of purines and its
importance.
b. Biologically active nucleotides.
d. Antioxidant Vitamins Rear
e. Glycemic Index
3. Comment and justify on any six of the
following: (6)
b. Replication is semi-conservative.
c. Hemolysed samples should not be used
for estimation of Potassium.
d. Puromycin results in production of
e. Hyperammonemia is toxic.
f. Methotraxate is an anticancer drug.
g. Serum TIBC is increased in iron deficiency
anemia.
process.
***
First Year MBBS Examination
I MBBS Biochemistry Paper 2
Time: 3 hours
Max Marks: 50
--- Content provided by FirstRanker.com ---
Date: 10-12-2019Instructions: 1. Answer to the points. 2. Figure
to the right indicates marks. 3. Use separate
answer books for each section. 4. Draw
diagrams wherever necessary. 5. Write legibly.
--- Content provided by FirstRanker.com ---
Section 11. Give an account on any two (10)
a. Causes and deficiency manifestations of
Vitamin B12.
b. Repair mechanism of damaged DNA and
--- Content provided by FirstRanker.com ---
associated disorders.c. Recombinant DNA Technology and its
applications.
2. Write Short Note on any three (9)
a. Phase I reactions of detoxification
--- Content provided by FirstRanker.com ---
mechanism.
b. Use of Radio-isotopes in Medicine.
c. Gene Therapy.
d. Plasma proteins as diagnostic tools.
e. Lac operon.
--- Content provided by FirstRanker.com ---
3. Read the following case and answer in two orthree lines: A 65 years old man presented
With back pain, loss of weight and
breathlessness. On examination he was (6)
anaemic. Investigations showed:Hb
--- Content provided by FirstRanker.com ---
7gm/dL,Serum totalproteins:10.5gm/dL,albumin 3 gm/dl.scrum
urca 48 gm/dl, serum Creatinine 2.4mg/dL
serum protein electrophoresis showed M
band in gamma region. In urine, Bence
--- Content provided by FirstRanker.com ---
dones Protein were present. Radiologicalexamination showed punched out lytic
lesions in lumbar vertebrae, ribs, pelvis
vertebrae, ribs and pelvis.
a. What is the likely diagnosis?
--- Content provided by FirstRanker.com ---
b. Enlist any two other conditions in which A-G ratio is reversed.
c. What are Bence Jones Proteins?
d. What is the normal pattern of serum
proteins in electrophoresis?
--- Content provided by FirstRanker.com ---
e. How are paraproteins (Mycloma Proteins)different from normal immunoglobulin
molecule?
f. How Bence Jones Proteins are detected in
urine?
--- Content provided by FirstRanker.com ---
Section 21. Give an account on any two: (10)
a. Protein Energy Malnutrition (PEM).
b. Sources, absorption, transport, functions
and disorders of Calcium,
--- Content provided by FirstRanker.com ---
c. Disorders of Aromatic Amino Acids.2. Write Short Note on any three (9)
a. Salvage pathway of purines and its
importance.
b. Biologically active nucleotides.
--- Content provided by FirstRanker.com ---
c. Wald's Visual Cycle.d. Antioxidant Vitamins Rear
e. Glycemic Index
3. Comment and justify on any six of the
following: (6)
--- Content provided by FirstRanker.com ---
a. Lead poisoning causes anemia.b. Replication is semi-conservative.
c. Hemolysed samples should not be used
for estimation of Potassium.
d. Puromycin results in production of
--- Content provided by FirstRanker.com ---
incomplete proteins.e. Hyperammonemia is toxic.
f. Methotraxate is an anticancer drug.
g. Serum TIBC is increased in iron deficiency
anemia.
--- Content provided by FirstRanker.com ---
h. Vitamin K is required for blood coagulationprocess.
***