Second Year MBBS Examination
II MBBS Pathology Paper 1 (New)
Time: 3 hours
Max Marks: 100
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Instructions:1. Answer to the points.
2. Figure to the right indicates marks.
3. Use separate answer books for each section.
4. Draw diagrams wherever necessary.
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5. Write legibly.Section 1
1. Structured long questions (any one out of two)
(10)
a. Define reversible cell injury. Describe role of
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oxygen derived free radicals in cell injury,Describe ischemia-reperfusion injury.1+5+4
b. Define acute inflammation, Describe
leukocytes recruitments at the site of
inflammation. Describe leukocytes mediated
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tissue injury.1+6+32. A. Applied short notes (any two outof three)
2x6=12 (12)
a. A 68 year old male with chronic cardiac
disease and chronic liver disease presented
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to OPD with presence of edema in dependentportion of the body Explain the
pathophysiology of edema in this patient
Describe various types of edema.
b. A 48 year female presented to OPD with
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large deep ulcer over dorsal aspect of foot.Describe the mechanism by which wound
healing occur in this patient. Enumerate the
complications arise in tissue repair.
c. A 17 year female presented to surgery OPD
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with profuse watery diarrhoea, abdominalpain and occasional blood in stool. On
colonoscopy there are >100 adenomatous
polyps are present in large colon.Patient is
suffering from which inherited condition?
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Which tumor suppressor gene gets mutatedin this case? Describe WNT signalling
pathway.
3. B. Write short notes on. (any three out of four)
3x6=18 (18)
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a. Autoimmune diseasesb. Radiation injuries
c. Fetal hydrops
d. Chemical carcinogenesis
4. Answer in two to three sentences only
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5x2=10(any five out of six) (10)
2. What is genomic imprinting?
3. Difference between hyperaemia and
congestion.
4. Give four examples of chronic granulomatous
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inflammation.5. Difference between transudate and exudate.
6. What is Cellular Senescence?
Section 2
1. Structured long questions (any one out of two)
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(10)a. Classify anaemia according to their
morphology. Discuss iron metabolism.
Describe etiology, clinical features and
laboratory diagnosis of iron deficiency
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anaemia.1+2+2+2+3b. Classity lymphoid neoplasm according to
WHO,Describe pathogenesis, prognostic
factors and laboratory diagnosis of acute
lymphoblastic leukaemia.3+2+2+3
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2. A. Applied short notes (any two out of three)(12)
a. A 33 year old male patient presented to
emergency department by ambulance who
isthe victim of major road traffic accsident.
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During assessment there is open tibialfracture for which he is bleeding patient is
taken to operation theatre for a operation of
fracture for which consent is taken. Patient
gave past history of tonsillectomy for which
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he need blood transfusion. Patient has givenone unit of blood transfusion. Ten minutes
later patient becomes increasingly nauseous,
sweaty shortness of breath and feels dizzy.
On examination his Spo2:94%, Pulse rate:
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110/min, BP: 94/64mmhg and Respiratoryrate: 28/min.Blood investigation shows
Hb:8.8 gm/dl, WBC:20000/cumm, direct
antiglobulin test is positive and Urine shows
haemoglobinuria. Why this patient gets
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deteriorated after blood transfusion? Whydirect antiglobulin test is positive? What is
the difference between direct antiglobulin and
indirect antiglobulin test?
b. A 10 year female abruptly develops petechia
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all over body,easy bruising and bleedinggums. Patient has history of viral fever few
weeks back. Complete blood count is carried
out which shows Hb:2gm/dl,
WBC:8000/cumm, Platelet count:
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90000/cumm. what is your probablediagnosis. Describe the pathogenesis of the
condition. What are the common causes of
decreased platelet counts?
c. Describe pathogenesis and laboratory
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diagnosis of Multiple Myeloma.3. B. Write short notes on. (any three out of four)
(18)
a. Sickle cell disease
b. Immune mediadiated hemolytic anaemia
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c. Agranulocytosisd. Single donor platelets
4. Answer in two to three sentences only (five out
of six) (10)
a. Mention four transfusion transmitted
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infections.b. Prognostic factors of chronic lymphocytic
leukaemia.
c. What is leukocytes reduction in component
separation and what are the clinical benefits
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of leukocytes reduction component therapy?d. Name two myeloproliferative disorders
associated with JAK2 point mutation
e. What is HbH disease?
f. What is Glanzmann thrombasthenia?
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