Download MBBS 1st Year 2024 September 526056 Biochemistry Paper II Theory Question Paper

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[MBBS 0924]
SEPTEMBER 2024 Sub. Code : 6056

M.B.B.S. DEGREE EXAMINATION
(For the candidates admitted from the Academic Year 2020 -2021 Onwards)

FIRST PROFESSIONAL ? (CBME) - SUPPLEMENTARY
PAPER II ? BIOCHEMISTRY
Q.P. Code: 526056

Time: Three hours
Maximum : 100 Marks (80 Theory + 20MCQs)
Answer All Questions
I. Essay:



(2 x 15 = 30)
1. Explain how mRNA synthesized in the cytoplasm is translated into a protein with
suitable diagram? Add a note on Post translational modification.
2. Explain how Phenylalanine is both a ketogenic and glucogenic amino acid.
Add a note on inborn errors associated with Phenylalanine.

II. Write notes on:




(10 x 5 = 50)
1. Write a note on the following:
a) Hartnup's disease.
b) Secondary orotic aciduria.
c) How does the supplementation of vitamin B6, B12 and folic acid help in the
management of homocystinuria.
2. Short note on the DNA repair system which is defective in hereditary
nonpolyposis colon cancer. Mechanism of action of Methotrexate and
Actinomycin D as anticancer drugs.
3. A 5-year-old male child with uneventful birth history was brought with c/o self
injurious behavior, irritability and emotional lability for the past 2 years. From
the age of 3 yrs he started biting his lips, tongue and banging his head over the
wall and scratching his face (self-mutilation). Developmental history revealed
delayed milestones. Serum uric acid level was 9.5 mg/dL.
a) What is your probable diagnosis?
b) Enumerate the biochemical basis of the neurological manifestations in this disease.
c) Discuss the salvage pathway for Purine synthesis.
4. Explain the catabolism of Tryptophan to serotonin and its clinical features.
5. Mention five tumour markers with their diagnostic importance.
6. What are the types of gene therapy? Give examples of any three diseases for
which gene therapy has beneficial effects?
7. Polymerase chain Reaction.
8. How will you explain to the patient that his blood cholesterol levels are high?
9. What is quality control? Explain the types of quality control.
10. Interpret the following Liver Function Test report:
Total
Direct
Alkaline
Ehrlich's
Stool
bilirubin
bilirubin
phosphatase
test
sample
7.7 mg/dL
3.6 mg/dL
265 IU/L
Negative
Clay colour
a) What is the probable diagnosis?
b) Mention the possible causes for the above condition.
c) Substantiate with reasons for increase in conjugated fraction of Bilirubin.
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