Download DNB 2020 December Pharmacology Paper I Question Paper

Download Diplomate of National Board (DNB) 2020 December Pharmacology Paper I Question Paper

FINAL EXAM
NATIONAL BOARD OF EXAMINATIONS
DECEMBER 2020
PHARMACOLOGY
PAPER-I
Time: 3 hours
PHARMA/D/20/34/I
Max. Marks:100
Important Instructions:
You are provided with 5 answer sheet booklets. Each individual answer sheet booklet consists
of 10 pages excluding the covering jackets.
Answers to all the questions must be attempted within these 5 answer sheet booklets which
must be later tagged together at the end of the exam.
No additional supplementary answer sheet booklet will be provided.
Attempt all questions in order.
Each question carries 10 marks.
Read the question carefully and answer to the point neatly and legibly.
Do not leave any blank pages between two answers.
Indicate the question number correctly for the answer in the margin space.
Answer all the parts of a single question together.
Start the answer to a question on a fresh page or leave adequate space between two answers.
Draw table/diagrams/flowcharts wherever appropriate.

Write short notes on:

1.
Write the significance of steady state of a drug. Define and explain
5+5
the role of pharmacokinetics in determining:
a) Loading dose.
b) Maintenance dose.
2.
How is bio-equivalence different from bio-availability? Highlight the
5+5
difficulties in determining bioequivalence between the innovator
molecule with its bio-similar in biologic drugs.
3.
What are isobolograms? Mention their role in determining
10
combined drug effects.
4.
Mention drug delivery systems or formulations that are used for

5+5
providing constant drug concentration in the body over long
periods? How do they achieve their therapeutic benefit compared
to other dosage forms?
5.
Discuss the differences between Graded versus Quantal Dose
5+5
Response Curve. Describe the clinical relevance of studying these
curves.
6.
Describe pharmacokinetics. Differentiate between first and zero
2+6+2
order kinetics. Write the clinical significance of knowing the kinetic
order of a drug.
7.
Define therapeutic drug monitoring. Mention the characteristics of
2+6+2
drugs which are the appropriate candidates for therapeutic drug
monitoring. Describe precautions while doing therapeutic drug
monitoring.
P.T.O.
-1-
POSSESSION/USE OF CELL PHONES OR ANY SUCH ELECTRONIC GADGETS IS NOT PERMITTED INSIDE THE
EXAMINATION HALL.

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FINAL EXAM
NATIONAL BOARD OF EXAMINATIONS
DECEMBER 2020
PHARMACOLOGY
PAPER-I
8.
a) Gender based differences in drug therapy.

5 +5
b) Environmental Pharmacology.
9.
a) Spurious drugs.

5+5
b) Designer drugs.
10.
Explain what you under by drug antagonism. Enumerate different
3+2+5
types of antagonists in pharmacology. Explain details of receptor
antagonism.
*************
-2-
POSSESSION/USE OF CELL PHONES OR ANY SUCH ELECTRONIC GADGETS IS NOT PERMITTED INSIDE THE
EXAMINATION HALL.

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