Download DNB 2020 December Pharmacology Paper III Question Paper

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FINAL EXAM

DECEMBER 2020

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PHARMACOLOGY

PAPER-III

PHARM/D/20/34/III

Time: 3 hours

Max. Marks:100

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Important Instructions:

• You are provided with 5 answer sheet booklets. Each individual answer sheet booklet consists of 10 pages excluding the covering jackets.
• Answers to all the questions must be attempted within these 5 answer sheet booklets which must be later tagged together at the end of the exam.
• No additional supplementary answer sheet booklet will be provided.
• Attempt all questions in order.

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• Each question carries 10 marks.
• Read the question carefully and answer to the point neatly and legibly.
• Do not leave any blank pages between two answers.
• Indicate the question number correctly for the answer in the margin space.
• Answer all the parts of a single question together.

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• Start the answer to a question on a fresh page or leave adequate space between two answers.
• Draw table/diagrams/flowcharts wherever appropriate.

Write short notes on:

1. 5+5

   1. pA2.

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   2. Nocebo response.

2. 7+3

   Briefly discuss analysis of variance (ANOVA) with an example. List three post hoc tests commonly used after results are significant for ANOVA.

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3. 10

   Describe various preclinical screening methods for evaluation of a new antihypertensive drug.

4. 6+4

   Elucidate the three Rs for animal experiments. Explain in brief any four alternatives to animal experiments.

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5. 2+8

   Define meta-analysis. Explain in brief the steps involved in carrying out a meta-analysis.

6. 10

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   How should preclinical evaluation of antidiabetic drugs be carried out?

7. 5+5

   What is null and alternate hypothesis in superiority and non-inferiority clinical trials? Explain type I and type II errors with examples.

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8. 10

   Purpose and principles of “Good Clinical Practices".

9. 3+7

   Enumerate pre-clinical systemic toxicity studies for evaluation of a drug candidate. Briefly write the procedure to carry out acute toxicity studies.

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10. 7+3

    Principle of high-performance liquid chromatography (HPLC) and its application in research.

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POSSESSION/USE OF CELL PHONES OR ANY SUCH ELECTRONIC GADGETS IS NOT PERMITTED INSIDE THE

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