Download DNB 2020 December Pharmacology Paper III Question Paper

Download Diplomate of National Board (DNB) 2020 December Pharmacology Paper III Question Paper

FINAL EXAM
NATIONAL BOARD OF EXAMINATIONS
DECEMBER 2020
PHARMACOLOGY
PAPER-III

Time: 3 hours
PHARM/D/20/34/III
Max. Marks:100
Important Instructions:
You are provided with 5 answer sheet booklets. Each individual answer sheet booklet consists
of 10 pages excluding the covering jackets.
Answers to all the questions must be attempted within these 5 answer sheet booklets which
must be later tagged together at the end of the exam.
No additional supplementary answer sheet booklet will be provided.
Attempt all questions in order.
Each question carries 10 marks.
Read the question carefully and answer to the point neatly and legibly.
Do not leave any blank pages between two answers.
Indicate the question number correctly for the answer in the margin space.
Answer all the parts of a single question together.
Start the answer to a question on a fresh page or leave adequate space between two answers.
Draw table/diagrams/flowcharts wherever appropriate.

Write short notes on:

1. a) pA2.
5+5
b) Nocebo response.
2. Briefly discuss analysis of variance (ANOVA) with an example. List three
7+3
post hoc tests commonly used after results are significant for ANOVA.
3. Describe various preclinical screening methods for evaluation of a new
10
antihypertensive drug.
4. Elucidate the three Rs for animal experiments. Explain in brief any four
6+4
alternatives to animal experiments.
5. Define meta-analysis. Explain in brief the steps involved in carrying out a
2+8
meta-analysis.
6. How should preclinical evaluation of antidiabetic drugs be carried out?
10
7. What is null and alternate hypothesis in superiority and non-inferiority clinical
5+5
trials? Explain type I and type II errors with examples.
8. Purpose and principles of "Good Clinical Practices".
10
9. Enumerate pre-clinical systemic toxicity studies for evaluation of a drug
3+7
candidate. Briefly write the procedure to carry out acute toxicity studies.
10. Principle of high-performance liquid chromatography (HPLC) and its
7+3
application in research.
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POSSESSION/USE OF CELL PHONES OR ANY SUCH ELECTRONIC GADGETS IS NOT PERMITTED INSIDE THE
EXAMINATION HALL.

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