Q. 1) Which of the following presents with Palatal edema
a) Alpha heavy chain disease
b) Gamma heavy chain disease
c) Mu chain disease
--- Content provided by FirstRanker.com ---
d) Beta heavy chain diseaseAnswer B .
Q.2) Which of the following gene is mutated in MDS with ring sideroblasts
a) SF3B1
b) P 5 3
--- Content provided by FirstRanker.com ---
c) TETd) PTEN
Answer. A. SF3B1
Q.3) Which of the following has good prognosis In myeloma
a) t(11,14)
--- Content provided by FirstRanker.com ---
b) t(14,18)c) del 17
d) t(14,16)
Answer - a. t(11,14)
Q.4) Ditra syndrome is associated with mutation in
--- Content provided by FirstRanker.com ---
a) I L3 6b) I L4 6
c) IL10
d) IL26
Answer a. IL36
--- Content provided by FirstRanker.com ---
Q5) Blau syndrome is associated with mutation ina) NOD2/CARD 15
b) ?
c) ?
d) ?
--- Content provided by FirstRanker.com ---
Answer a. NOD2JIPMER May 2018. Version 1 ? Compiled by Dr. Ranjith AR
Need other options ? Answer is NOD2/CARD15
Q. 6) Normal value of E PO is
a) 5 - 1 5
--- Content provided by FirstRanker.com ---
b) 1 5 - 2 5c) 4 5 - 5 5
d) 55-65
Answer?. ____
This is confusing. I will quote the standards we use in our lab for reporting
--- Content provided by FirstRanker.com ---
Harrison quotes - 4-27 as normal ? I am inclined to option A. Will discuss withphysicians and will let you know about the practice.
Q. 7) Mutation in Alp ort syndrome
a) COL3A4
b) ?
--- Content provided by FirstRanker.com ---
c) ?d) ?
Answer A. COL3A4
NEED OTHER OPTIONS
Q.8) A 50 year old women who was obese and hypertensive, came with complaints of
--- Content provided by FirstRanker.com ---
bleeding and abdomen pain, diagnosed to be endometrial cancer. Which of the followinggene is mutated?
a) P 5 3
b) PTEN
c) Beta catenin
--- Content provided by FirstRanker.com ---
d)Answer PTEN
JIPMER May 2018. Version 1 ? Compiled by Dr. Ranjith AR
Going with PTE N because it's the most common one mutated (Ref. WHO - >50%)
Q. 9) location of B C L2 is
--- Content provided by FirstRanker.com ---
a) Cytoplasmb) Cell wall
c) Mitochondria
d) Nucleus
Answer ? Mitochondria
--- Content provided by FirstRanker.com ---
Q. 1 0) Call exner bodies are seen ina) Granulosa cell tumor
b) Yolk sac
c) Dysgerminoma
d) Embryonal carcinoma
--- Content provided by FirstRanker.com ---
Answer A.Q.11) Origin of Waldenstorm Macroglobulinemia is
a) Germinal centre T cell
b) Germinal centre B cell
c) Post germinal centre T cell
--- Content provided by FirstRanker.com ---
d) Post germinal centre B cellAnswer D .
Q.12) CNS involvement in DLBCL is not seen with which of the following organ
involvement
a) Ovary
--- Content provided by FirstRanker.com ---
b) Testisc) Kidney
d) Adrenal
Answer a. Ovary
Ref WHO ? CNS lymphoma are at increase risk when DLBCL involves kidney and
--- Content provided by FirstRanker.com ---
adrenals, and testicular D LB C L is closely linked with C N S D LB C LQ. 1 3) Para proteins are seen in
a) C LL
b) RA
c) Scleroderma
--- Content provided by FirstRanker.com ---
d) LymphomaAll of them have paraproteins. Need a good recall.? Anything missing?
JIPMER May 2018. Version 1 ? Compiled by Dr. Ranjith AR
Q. 1 4) Which of the following is AD
a) Bests disease
--- Content provided by FirstRanker.com ---
b) Laurence moon biedlc) ?
d) ?
Answer- Bests disease
Need rest options
--- Content provided by FirstRanker.com ---
Q.15) Eosin 5 Maleamide flow cytometry is used for diagnosis ofa) G6PD
b) H S
c) Sickle cell anemia
d) Not recalled
--- Content provided by FirstRanker.com ---
Answer B . H SE MA - Flow cytometry method to detect HS.
Q.16) Northern blotting used for separation nd diagnosis of.
A. Histones
B protiens
--- Content provided by FirstRanker.com ---
C . RnaD . Dna
Answer RNA
Q.17) Most immunogenic blood group
a) Kell
--- Content provided by FirstRanker.com ---
b) Duffyc) Kidd
d) Not recalled
Answer ? kell
Q.18) Mutation in Hartnup disease
--- Content provided by FirstRanker.com ---
a) SLC6A19b) ?
c) ?
d) ?
Answer SLC6A19 ? Recall other options
--- Content provided by FirstRanker.com ---
Q. 1 9) Shilling test false statementJIPMER May 2018. Version 1 ? Compiled by Dr. Ranjith AR
a) Oral Radiolabelled B12 is given
b) Unlabeled B12 is given IM
c) Vit B12 excreted in urine
--- Content provided by FirstRanker.com ---
d) Abnormal test rules out intestinal malabsorptionAnswer ? D.
Abnormal test of Schilling 1 should be followed up with Schilling II (with IF) then with
oral antibiotics and pancreatic enzyme.
Q.20) 40 age women on treatment for CLL. Over the past few months she noticed
--- Content provided by FirstRanker.com ---
swellings in the neck and axilla which was rapidly increasing in size. She complains offeeling feverish and experiences weight loss. Which of the following is responsible
a) Richter transformation
b) Progression of CLL
c) EBV infection
--- Content provided by FirstRanker.com ---
d) Immunodeficint hemolytic anemiaAnswer. A. I would go with A.
We have first two options to worry.
C LL ? progress to PLL (Pro lymphocytic leukemia) PLL generally presents with
Splenomegaly, More WBC count and low platelet count.. Those are the symptoms.
--- Content provided by FirstRanker.com ---
Direct lines from book"Richter Syndrome, which is defined as the transformation of CLL into an aggressive
lymphoma (most commonly diffuse large B-cell lymphoma) occurs in 5?10% of all
cases. The syndrome may be suspected if there are signs of aggressive disease, such as
impairment of performance status, presence of B symptoms, and rapid increase in the
--- Content provided by FirstRanker.com ---
size of lymph nodes"Q.21) False about micro satellites is
a) Repeat size more than 10 to 15 nucleotides
b) More prone to variation
c) Found in colonic carcinoma
--- Content provided by FirstRanker.com ---
d) DNA repeatsAnswer A
Microsatellite by definition is between 2-6 nucleotides in length. Not more that that.
They are more prone for variation between individuals., the number of repeat varies
from one person to another.
--- Content provided by FirstRanker.com ---
Microsatellite instability is one of the causes of Colon cancer.JIPMER May 2018. Version 1 ? Compiled by Dr. Ranjith AR
Q . 2 2 ) True about single donor platelet transfusion
a) Equal to 6-8 RDP
b) Stored in 2- 6
--- Content provided by FirstRanker.com ---
c) 10 days shelf lifed) Not recalled
Answer is A.
Room temperature, 5 days,
Q. 2 3) Increase in D-dimer with immediate post surgery period. Most appropriate
--- Content provided by FirstRanker.com ---
diagnosis isa) DVT
b) Pulmonary embolism
c) D I C
d) Normal
--- Content provided by FirstRanker.com ---
Answer ? d NormalImmediate post ?op D dimer rise is normal. Immediate post op that's one of the
limitations of using d-dimer. If the question is immediate post op, it is normal.
D-dimer returns back to baseline depending on the type of surgery. (There is a
classification based on that - Type 1 ? not entering abdomen, type II ? abdominal cavity,
--- Content provided by FirstRanker.com ---
type III ? retroperitoneal/liver)Q.24) All of the following are seen in RASopathies except
a) Hair abnormalities
b) Cranio facial abnormalities
c) Keratosis pilaris
--- Content provided by FirstRanker.com ---
d) Desquamation of skinAnswer is d.
RASopathies include - These disorders include neurofibromatosis type 1 (NF1), Noonan
syndrome (NS), Noonan syndrome with multiple lentigines (NSML), capillary
malformation?ateriovenous malformation syndrome (CM-AVM), Costello syndrome
--- Content provided by FirstRanker.com ---
(CS), cardio-facio-cutaneous syndrome (CFC), and Legius syndrome.Ectodermal findings typically consist of sparse, curly hair with sparse eyebrows and
eyelashes, hyperkeratosis, keratosis pilaris, hemangioma, ichthyosis, and progressively
forming nevi
JIPMER May 2018. Version 1 ? Compiled by Dr. Ranjith AR
--- Content provided by FirstRanker.com ---
Q. 2 5) Which of the following is true about Nodular Regenerative Hyperplasia.a . Nodule size 0.1 to 1 cm
b . Fibrosis septa present
c. Portal hypertension seen in 50% of patients
d . AST and ALT are markedly elevated
--- Content provided by FirstRanker.com ---
Answer C .1 -3 mm diameter nodules
No fibrosis, only nodules
Presents as non-cirrhotic portal hypertension
AST ? ALT mild elevation or normal
--- Content provided by FirstRanker.com ---
Q. 2 6) Something on GIST markerQ. 2 7) H emosi derin as marker
Q. 2 8) Which of the following is true regarding BCR ABL transcript
a . Please recall correct options...
Q. 2 9) Question on S LE
--- Content provided by FirstRanker.com ---
Q.30) Question on hemolytic anemiaQ. 3 1 ) Question on vinyl chloride
Q. 3 2 )
Comment below if any additional questions. Will upload the complete version soon. J
All the best guys, keep rocking!!
--- Content provided by FirstRanker.com ---