Download DNB 2020 June Biochemistry Paper II Question Paper

Download Diplomate of National Board (DNB) 2020 June Biochemistry Paper II Question Paper

FINAL EXAM
NATIONAL BOARD OF EXAMINATIONS
JUNE 2020
BIOCHEMISTRY
PAPER-II
Time: 3 hours
BCHEM/J/20/03/II
Max. Marks:100
Important Instructions:
Attempt al questions in order.
Each question carries 10 marks.
Read the question careful y and answer to the point neatly and legibly.
Do not leave any blank pages between two answers.
Indicate the question number correctly for the answer in the margin space.
Answer all the parts of a single question together.
Start the answer to a question on a fresh page or leave adequate space between two answers.
Draw table/diagrams/flowcharts wherever appropriate.
Write short notes on:
1. Explain how:
4+6
a) Phenylketonuria causes mental retardation and skin pigment disorder
if not managed properly within first five years of life.
b) Kreb's bicycle effectively links the fates of amino groups
and carbon skeleton of the amino acids.
2. a) Leukotriene synthesis, function, pathogenetic role and its inhibitors.
7+3
b) Excretion of cholesterol from human body.
3. Explain how:
4+3+3
a) Cyanide exert its toxicity and its toxicity managed.
b) Thermogenin helps to maintain body temperature in hibernating
animals and new born babies.
c) Thermodynamically unfavourable biochemical reactions occur in
human body.
4. a) Role of leptin in obesity.
5+5
b) Biochemical markers of malnutrition.
5. a) How is heme synthesized?
6+4
b) Write biochemical basis of presentation of porphyria cases with acute
abdomen and cutaneous lesion.
6. Explain why:
4+3+3
a) Vitamin B12 deficiency leads to megaloblastic anaemia.
b) Folic acid should not be given alone when its deficiency coexists with
vitamin B12 deficiency.
c) Histidine load test is negative in vitamin B12 deficiency.
7. Define dietary fiber. Classify them. Write their functions and therapeutic
2+2+4+2
uses.
P.T.O.
-1-
POSSESSION/USE OF CELL PHONES OR ANY SUCH ELECTRONIC GADGETS IS NOT PERMITTED INSIDE THE
EXAMINATION HALL.

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FINAL EXAM
NATIONAL BOARD OF EXAMINATIONS
JUNE 2020
BIOCHEMISTRY
PAPER-II
8. Explain why:
3+4+3
a) AMP concentration is a more sensitive indicator of the cell's energetic
state than that of ATP.
b) Deficiency of pyruvate kinase leads to haemolytic anaemia.
c) Patient on haemodialysis is administered carnitine to prevent
development of hypoglycaemia.
9. Write biochemical basis of physiological serum cholesterol homeostasis,
3+4+3
hypercholesterolemia in hypothyroidism and diabetes and their
management.
10. Define sub-clinical hypothyroidism. How primary, secondary and tertiary
2+8
hypothyroidism can be differentiated by thyroid function testing in
laboratory.
************
-2-
POSSESSION/USE OF CELL PHONES OR ANY SUCH ELECTRONIC GADGETS IS NOT PERMITTED INSIDE THE
EXAMINATION HALL.

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