Download DNB 2020 June Biochemistry Paper III Question Paper

FINAL EXAM
NATIONAL BOARD OF EXAMINATIONS
JUNE 2020
BIOCHEMISTRY
PAPER-III

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Time: 3 hours
BCHEM/J/20/03/III
Max. Marks:100
Important Instructions:
Attempt al questions in order.

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Each question carries 10 marks.
Read the question careful y and answer to the point neatly and legibly.
Do not leave any blank pages between two answers.
Indicate the question number correctly for the answer in the margin space.
Answer all the parts of a single question together.

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Start the answer to a question on a fresh page or leave adequate space between two answers.
Draw table/diagrams/flowcharts wherever appropriate.
Write short notes on:
1. Explain how:
7+3

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a) Replication of both leading and lagging strands of DNA are carried out
by a single DNA polymerase enzyme complex in a single direction of
the replication fork.
b) Fluoroquinolones function as effective inhibitors of prokaryotic DNA
replication.

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2. a) Mechanism and clinical implications of defects in nucleotide excision
6+4
repair system.
b) Role of DNA recombination in DNA repair system.
3. a) Next generation sequencing of DNA,

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5+5
b) Role of introns in splicing mechanisms.
4. Describe in brief the importance of:
6+4
a) Genome wide association study.

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b) mRNA editing in regulation of lipid metabolism.
5. Write brief explanatory notes on:
4+6
a) Maintenance of stringency of genetic code by Aminoacyl tRNA
synthetases,

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b) Protein targeting failure.
6. Describe the regulation of eukaryotic gene expression by:
5+5
a) Si (smal interfering) RNAs.
b) Epigenetic mechanisms.

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7. Explain how:
6+4
a) Antibody diversity occurs.
b) Expression sequence tagging (EST) helps in the mapping of genome.
P.T.O.

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POSSESSION/USE OF CELL PHONES OR ANY SUCH ELECTRONIC GADGETS IS NOT PERMITTED INSIDE THE
EXAMINATION HALL.

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FINAL EXAM
NATIONAL BOARD OF EXAMINATIONS

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JUNE 2020
BIOCHEMISTRY
PAPER-III
8. a) DNA vaccines.
4+6

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b) Cytokine storm and its clinical importance.
9. Explain in brief:
5+5
a) Targeted cancer therapy.
b) Biochemical basis of metastasis of malignant cel s.

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10. a) BRCA1 and BRCA2 as tumour suppressor genes.
5+5
b) Production of monoclonal antibodies by hybridoma technique.
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POSSESSION/USE OF CELL PHONES OR ANY SUCH ELECTRONIC GADGETS IS NOT PERMITTED INSIDE THE
EXAMINATION HALL.

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