Download DNB 2020 June Nephrology Paper I Question Paper

Download Diplomate of National Board (DNB) 2020 June Nephrology Paper I Question Paper

FINAL EXAM
NATIONAL BOARD OF EXAMINATIONS
JUNE 2020
NEPHROLOGY
PAPER-I
Time: 3 hours
NEPH/J/20/20/I
Max. Marks:100
Important Instructions:
Attempt al questions in order.
Each question carries 10 marks.
Read the question careful y and answer to the point neatly and legibly.
Do not leave any blank pages between two answers.
Indicate the question number correctly for the answer in the margin space.
Answer al the parts of a single question together.
Start the answer to a question on a fresh page or leave adequate space between two answers.
Draw table/diagrams/flowcharts wherever appropriate.
Write short notes on:
1. Vasoactive peptides in kidneys:
3+5+2
a) Enumerate vasoactive peptides in acting in kidneys.
b) Their role electrolyte exchange regulation.
c) Clinical utility of endothelin antagonists.
2. Clinical studies:
7+3
a) Compare and contrast observational studies with randomised
clinical trials.
b) Analysis of variance and statistical significance.
3. Plasma cel dyscrasias:
3+3+4
a) Classification.
b) Diagnostic criteria of monoclonal gammopathy of renal
significance.
c) Light chain induced renal damage.
4. Hypokalemia:
5+3+2
a) Diagnostic approach to a patient with hypokalemia.
b) Enumerate renal abnormalities in prolonged hypokalemia.
c) Management of Bartter's syndrome.
5. Peritoneal dialysis:
4+3+3
a) Relevance of PET test in CAPD.
b) What is three pore model of peritoneal membrane?
c) Define ultrafiltration failure in PD and its types.
6. Anaemia in chronic kidney disease:
4+3+3
a) Kidney's response to hypoxia.
b) Role of hepcidin.
c) Role of HIF stabilizers.
7. Magnesium metabolism:
4+3+3
a) Enumerate factors affecting reabsorption of magnesium in the kidney.
b) Pathophysiology of hypomagnesemia induced hypokalemia.
c) Describe pharmacologic management of hypomagnesemia.
P.T.O
-1-
POSSESSION/USE OF CELL PHONES OR ANY SUCH ELECTRONIC GADGETS IS NOT PERMITTED INSIDE THE
EXAMINATION HALL.

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FINAL EXAM
NATIONAL BOARD OF EXAMINATIONS
JUNE 2020
NEPHROLOGY
PAPER-I
8. Podocytopathy:
4+4+2
a) Podocyte pathophysiology.
b) Mechanism of podocyte injury in focal and segmental
glomerulosclerosis.
c) Role of parietal epithelial cel activation in glomerulus.
9. a) Describe the T cel receptor and antigen presenting cel interaction.
5+5
b) Costimulatory blockade.
10. Acute kidney injury in special situations:
5+5
a) COVID-19 infection.
b) Therapy with immune checkpoint inhibitors.
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-2-
POSSESSION/USE OF CELL PHONES OR ANY SUCH ELECTRONIC GADGETS IS NOT PERMITTED INSIDE THE
EXAMINATION HALL.

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