Download Diplomate of National Board (DNB) 2020 December ClInIcal Haematology Paper II Question Paper
NATIONAL BOARD OF EXAMINATIONS
DECEMBER 2020
CLINICAL HAEMATOLOGY
PAPER-II
Time: 3 hours
HEMAT/D/20/48/II
Max. Marks:100
Important Instructions:
You are provided with 5 answer sheet booklets. Each individual answer sheet booklet consists
of 10 pages excluding the covering jackets.
Answers to all the questions must be attempted within these 5 answer sheet booklets which
must be later tagged together at the end of the exam.
No additional supplementary answer sheet booklet will be provided.
Attempt all questions in order.
Each question carries 10 marks.
Read the question carefully and answer to the point neatly and legibly.
Do not leave any blank pages between two answers.
Indicate the question number correctly for the answer in the margin space.
Answer all the parts of a single question together.
Start the answer to a question on a fresh page or leave adequate space between two answers.
Draw table/diagrams/flowcharts wherever appropriate.
Write short notes on:
1. a) Name different types of Leukocyte adhesion deficiency (LAD) and
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enumerate differences between them.
b) Classical presentation and lab diagnosis of LAD.
c) How will you manage a case of LAD?
2. a) Define Massive blood transfusion.
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b) Describe the transfusion pathophysiology and principles of massive
blood transfusion.
c) Low titer Group O whole blood in transfusion medicine practice.
3. a) Immunoglobulin gene rearrangement.
4+3+3
b) Role of Natural Killer (NK) cells in the immune response of the human
body.
c) HLA restricted immune response.
4. a) What is leukemoid reaction? What are its causes?
3+4+3
b) Benign morphological abnormalities seen in neutrophils.
c) Cyclical neutropenia.
5. a) Criteria for donor selection for haplo-identical transplantation.
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b) Biomarkers for acute GVHD.
c) Sinusoidal obstruction syndrome.
6. a) Characteristics and indications for various plasma products.
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b) Transfusion associated graft-versus-host disease.
c) Diagnosis and management of platelet transfusion refractoriness.
P.T.O.
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POSSESSION/USE OF CELL PHONES OR ANY SUCH ELECTRONIC GADGETS IS NOT PERMITTED INSIDE THE
EXAMINATION HALL.
FINAL EXAM
NATIONAL BOARD OF EXAMINATIONS
DECEMBER 2020
CLINICAL HAEMATOLOGY
PAPER-II
7. a) Mention interaction of Monocytes and Macrophages with Platelets,
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Coagulation, and Fibrinolytic Cascades.
b) Classify histiocytic disorders.
c) Criteria for Hemophagocytic Lymphohistocytosis (HLH) in both
children and adults.
8. a) Mention functions of Eosinophil.
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b) A 23-year-old male presents with a white cell count of 45000/cumm
with 36% eosinophils. Describe the differential diagnosis, and
evaluation algorithm of this patient?
9. a) Briefly describe Pathogenesis of Human Immunodeficiency Virus
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Infection.
b) Describe the causes of anaemia in HIV infection.
c) How will you manage anemia in HIV infection?
10. a) Biomarkers and management of acute graft versus host disease.
4+3+3
b) Plerixafor salvage algorithms for Day minus 1 and Day Zero of
harvest during stem cell transplant.
c) Ruxolitinib in chronic GVHD.
*************
-2-
POSSESSION/USE OF CELL PHONES OR ANY SUCH ELECTRONIC GADGETS IS NOT PERMITTED INSIDE THE
EXAMINATION HALL.
This post was last modified on 31 July 2021