FINAL EXAM
DECEMBER 2020
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CLINICAL HAEMATOLOGY
PAPER-III
Time: 3 hours HEMAT/D/20/48/III
Max. Marks: 100
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Important Instructions:
- You are provided with 5 answer sheet booklets. Each individual answer sheet booklet consists of 10 pages excluding the covering jackets.
- Answers to all the questions must be attempted within these 5 answer sheet booklets which must be later tagged together at the end of the exam.
- No additional supplementary answer sheet booklet will be provided.
- Attempt all questions in order.
- Each question carries 10 marks.
- Read the question carefully and answer to the point neatly and legibly.
- Do not leave any blank pages between two answers.
- Indicate the question number correctly for the answer in the margin space.
- Answer all the parts of a single question together.
- Start the answer to a question on a fresh page or leave adequate space between two answers.
- Draw table/diagrams/flowcharts wherever appropriate.
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Write short notes on:
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A 50-year-old lady presents with back pain and anemia. 4+3+3
- Describe the approach to such a patient to rule out plasma cell disorder in this patient with notes on the differential diagnosis.
- Describe the ISS, R-ISS and mSMART risk stratification criteria.
- Describe the management of relapsed refractory multiple myeloma.
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a) Recommendations for thromboprophylaxis in pregnancy in patients with past history of post-partum thrombosis. 4+3+3
- Describe Global tests of coagulation.
- Reasons for and against thrombophilia testing.
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a) Mechanism of resistance to Tyrosine Kinase inhibitors in CML and strategies to overcome the resistance. 5+5
- Clinical & biologic factors associated with Treatment Free Remission in CML.
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a) Briefly mention the current status of Gene therapy for Hemophilia. 4+3+3
- What are obstacles for using AAV vector for above?
- Which alternative gene therapy approach showing promises recently?
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a) Enumerate and briefly describe the chief characteristics of all the types of vaccination available for SARS-CoV-2 in India and abroad. 3+3+4
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- What would be the recommendations of vaccination against SARS-CoV-2 in various groups of benign and malignant hematological diseases.
- Cytotoxic T cell infusion against any viral infections. P.T.O.
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1
POSSESSION/USE OF CELL PHONES OR ANY SUCH ELECTRONIC GADGETS IS NOT PERMITTED INSIDE THE
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A 40-year-old male presenting with fever and cervical lymphadenopathy 4+3+3
- Role of Brentuximab in the management of Hodgkin's lymphoma.
- Double hit and Double expresser lymphomas.
- Role of autologous transplant in peripheral T cell lymphomas.
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A 29-year-old man presents with fever, pancytopenia and coagulation abnormalities with Auer rods in peripheral smear. Discuss: 3+2+5
- Prognostic role of FLT3 mutation and other cytogenetic variants in acute promyelocytic leukaemia (APML).
- Role of autologous transplant in APML.
- Various chemotherapy regimens with brief highlight on anthracycline free double differentiating agents in APML.
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a) Describe the role of flowcytometric and genetic markers in prognosticating newly diagnosed chronic lymphocytic leukaemia. 3+4+3
- Risk stratified therapy for chronic lymphocytic leukaemia.
- Role of Allogeneic stem cell transplantation in the management of chronic lymphocytic leukaemia.
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a) Revised WHO 2016 diagnostic criteria for Polycythaemia Vera and management guidelines. 5+5
- IPSS-R risk stratification of myelofibrosis and management based on risk stratification.
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a) Immunotherapy in acute lymphoblastic leukaemia. 4+3+3
- BCR-ABL-like acute lymphoblastic leukaemia.
- Role of stem cell transplant in acute lymphoblastic leukaemia.
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2
POSSESSION/USE OF CELL PHONES OR ANY SUCH ELECTRONIC GADGETS IS NOT PERMITTED INSIDE THE
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This download link is referred from the post: DNB 2020 Dec Previous Question Papers-(Diplomate of National Board) Under NBE
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