Download DNB 2020 December ClInIcal Immunology And Rheumatology Paper I Question Paper

Time: 3 hours

Max. Marks: 100

RHM/D/20/43/I

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Important Instructions:

• You are provided with 5 answer sheet booklets. Each individual answer sheet booklet consists of 10 pages excluding the covering jackets.
• Answers to all the questions must be attempted within these 5 answer sheet booklets which must be later tagged together at the end of the exam.
• No additional supplementary answer sheet booklet will be provided.
• Attempt all questions in order.

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• Each question carries 10 marks.
• Read the question carefully and answer to the point neatly and legibly.
• Do not leave any blank pages between two answers.
• Indicate the question number correctly for the answer in the margin space.
• Answer all the parts of a single question together.

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• Start the answer to a question on a fresh page or leave adequate space between two answers.
• Draw table/diagrams/flowcharts wherever appropriate.

Write short notes on:

1. Discuss development of synovial joint. What are the sources of nutrition for articular cartilage?

   6+4

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2. Discuss the structure and function of skeletal muscle. Write short note on excitation-contraction coupling.

   (3+2)+5

3. Discuss different types of antigen presenting cells. Discuss the dendritic cell based therapy of arthritis.

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   5+5

4. Discuss different dendritic cell subsets and the role they play in Rheumatic disease.

   3+7

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5. Discuss about pro-inflammatory and regulatory monocytes. Draw flow diagram of autophagy pathway.

   5+5

6. Mechanism of calcineurin inhibitors and their role in lupus.

   4+6

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7. Differences between diagnostic and classification criteria and its implication. Write short note on over-diagnosis and over-treatment.

   7+3

8. Write about proteinases and their role in RA and OA.

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   5+5

9. Discuss IL-6 physiology and its implication in Rheumatic disease. Discuss anti IL-6 trials in systemic sclerosis.

   6+4

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10. What is meta-analysis and what are the steps in doing it? Write short note on Forest plot.

    7+3

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POSSESSION/USE OF CELL PHONES OR ANY SUCH ELECTRONIC GADGETS IS NOT PERMITTED INSIDE THE

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