NATIONAL BOARD OF EXAMINATIONS
JUNE 2020
PATHOLOGY
PAPER-I
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TIME: 3 HOURSPATH/J/20/32/I
MAX. MARKS: 100
Important Instructions:
Attempt al questions in order.
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Each question carries 10 marks.Read the question careful y and answer to the point neatly and legibly.
Do not leave any blank pages between two answers.
Indicate the question number correctly for the answer in the margin space.
Answer al the parts of a single question together.
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Start the answer to a question on a fresh page or leave adequate space between twoanswers.
Draw table/diagrams/flowcharts wherever appropriate.
Write short notes on:
1. Discuss mechanism of septic shock and MODS. Enumerate and
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elaborate the role of various serum prognostic markers of sepsis.5+(2+3)
2. Classify chromosomal defects. Give examples of each type. Elaborate
karyotyping and its use in detection of such defects.
3+2+5
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3. Discuss the mechanism of whole slide imaging. Enumerate andelaborate the utilization of the same in teaching and diagnostics.
5+(2+3)
4. a) Lesions of Alzheimer's disease.
b) Epigenetic changes in cancer.
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5+55. a) Regulators of angiogenesis.
b) HLA gene and autoimmunity.
5+5
6. a) Xenobiotics.
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5+5b) Cel ular and immunological interactions in an atherosclerotic
plaque.
7. What is tumor immunity? Elaborate on the mechanism of
immunotherapy.
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5+58. a) Liquid biopsy and its utility in cancer management.
5+5
b) Application of proteomics in cancer.
9. a) Fibrinoid necrosis.
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b) Cytosolic calcium and cel injury.5+5
10. Pathophysiology of bone healing.
10
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POSSESSION/USE OF CELL PHONES OR ANY SUCH ELECTRONIC GADGETS IS NOT PERMITTED INSIDE THE EXAMINATIONHALL.