Download DNB 2020 June Rheumatology Paper I Question Paper

Download Diplomate of National Board (DNB) 2020 June Rheumatology Paper I Question Paper

FINAL EXAM
NATIONAL BOARD OF EXAMINATIONS
JUNE 2020
RHEUMATOLOGY
PAPER-I
Time: 3 hours
RHM/J/20/43/I
Max. Marks:100
Important Instructions:
Attempt al questions in order.
Each question carries 10 marks.
Read the question careful y and answer to the point neatly and legibly.
Do not leave any blank pages between two answers.
Indicate the question number correctly for the answer in the margin space.
Answer al the parts of a single question together.
Start the answer to a question on a fresh page or leave adequate space between two answers.
Draw table/diagrams/flowcharts wherever appropriate.
Write short notes on:
1. What are adipokines? Name 4 adipokines? How does obesity contribute to
2+2+6
inflammation in rheumatoid arthritis?
2. Draw a diagram of IL-23/ IL-17 cytokine pathway. What is its pathogenetic
3+3+4
and therapeutic relevance in rheumatic diseases.
3. How is synovial fluid produced? What are its major constituents? How do
3+3+4
you analyze synovial fluid to dif erentiate different types of arthritis?
4. Discuss mechanisms of action of these 3 drugs as immunosuppressants:
3+4+3
a) Cyclophosphamide.
b) Hydroxychloroquine.
c) Mycophenolate mofetil.
5. What is the principle of Dual Energy X-Ray absorptiometry? What is its utility
5+5
in medical practice?
6. What is logistic regression analysis? Write its type and uses.
2+5+3
What is the difference between logistic regression and linear regression?
7. Discuss B cel development. What is the mechanism of action of Rituximab
3+4+3
(Anti-CD20 antibody)? What is the basis of relapse of a rheumatic disease
fol owing B cel depletion therapy?
8. Discuss different types of antigen presenting cel s. Discuss the dendritic cel
5+5
based therapy of arthritis.
9. Name five viruses commonly causing arthritis. What are the various
3+7
mechanisms by which viruses can cause arthritis?
10. What is the difference in the anatomy of smal , medium and large blood
4+3+3
vessels? Draw a line diagram of these three different blood vessels. How do
you classify vasculitis?
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POSSESSION/USE OF CELL PHONES OR ANY SUCH ELECTRONIC GADGETS IS NOT PERMITTED INSIDE THE
EXAMINATION HALL.

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