Download DNB 2020 June Surgical Oncology Paper I Question Paper

Download Diplomate of National Board (DNB) 2020 June Surgical Oncology Paper I Question Paper

FINAL EXAM
NATIONAL BOARD OF EXAMINATIONS
JUNE 2020
SURGICAL ONCOLOGY
PAPER-I
Time: 3 hours
SURGONCO/J/20/47/I
Max. Marks:100
Important Instructions:
Attempt al questions in order.
Each question carries 10 marks.
Read the question careful y and answer to the point neatly and legibly.
Do not leave any blank pages between two answers.
Indicate the question number correctly for the answer in the margin space.
Answer al the parts of a single question together.
Start the answer to a question on a fresh page or leave adequate space between two answers.
Draw table/diagrams/flowcharts wherever appropriate.
Write short notes on:
1. a) Briefly explain microbiota.
5+(3+2)
b) Enumerate the role of microbiota on.
i. Etiology of cancers.
i . Chemotherapy and immunotherapy.
2.
What is mismatch repair? What are the genes involved in MMR 2+2+3+3
deficiency? How does mismatch repair deficiency contribute to genomic
instability? Outline the clinical application of MMR deficiency.
3.
What is meant by immune surveil ance? Outline the mechanism of
2+4+4
action of checkpoint inhibitors and their clinical application.
4.
a) Discuss the current controversies in breast cancer screening.
5+5
b) Role of MRI in the screening and fol ow up of breast cancer.
5.
a) Role of indocyanine green in oncology.
5+5
b) Role of minimal y invasive surgery in gastric cancer.
6.
a) Types and mechanism of cancer angiogenesis.
5+5
b) Epithelial to mesenchymal transition.
7.
a) Oncological significance of Programmed Death-Ligand 1(PDL1)
5+5
protein.
b) Discuss the role of PDL 1 blockage in three malignancies, with
evidence.
8.
a) Anastomotic complications in esophageal surgery.
5+5
b) Prevention and management of thoracic duct injury on esophageal
surgery.
9.
a) What are the various targeted mutation analysis methods used in
5+3+2
oncology?
b) What is Sangers Sequencing?
c) FISH.
10. Define Apoptosis. Outline the mechanism of apoptosis and its clinical
2+(4+4)
application.
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POSSESSION/USE OF CELL PHONES OR ANY SUCH ELECTRONIC GADGETS IS NOT PERMITTED INSIDE THE
EXAMINATION HALL.

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