Download DNB 2020 December MedIcal Oncology Paper I Question Paper

FINAL EXAM

DECEMBER 2020

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MEDICAL ONCOLOGY

PAPER-I

Time: 3 hours MED.ONCO/D/20/17/1

Max. Marks:100

Important Instructions:

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• You are provided with 5 answer sheet booklets. Each individual answer sheet booklet consists of 10 pages excluding the covering jackets.
• Answers to all the questions must be attempted within these 5 answer sheet booklets which must be later tagged together at the end of the exam.
• No additional supplementary answer sheet booklet will be provided.
• Attempt all questions in order.
• Each question carries 10 marks.

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• Read the question carefully and answer to the point neatly and legibly.
• Do not leave any blank pages between two answers.
• Indicate the question number correctly for the answer in the margin space.
• Answer all the parts of a single question together.
• Start the answer to a question on a fresh page or leave adequate space between two answers.

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• Draw table/diagrams/flowcharts wherever appropriate.

Write short notes on:

1. a) Viruses and cancer. 3+4+3
   b) Drug resistance mechanisms in cancer.
   c) Chemotherapy related cancers.

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2. a) Hereditary colon rectal cancer. 3+4+3
   b) Microsatellite instability.
   c) KRAS and BRAF mutation in colon cancer.
3. a) Antibody-drug conjugates. 3+4+3
   b) Proteasome Inhibitors in cancer therapeutics.
   

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   c) mTOR inhibitors in treatment of cancer.
4. a) Enumerate tyrosine kinase inhibitors. 3+4+3
   b) Tyrosine kinase inhibitors in lung cancer.
   c) Tyrosine kinase inhibitors in renal cell carcinoma.
5. a) Principles of Radiotherapy. 3+4+3
   

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   b) Newer techniques of radiotherapy in CNS tumours.
   c) Radiation sensitizer.
6. a) Cell cycle. 3+4+3
   b) List CDK inhibitors.
   c) Indication of CDK inhibitors in breast cancer.

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7. a) Immune check point inhibitors. 3+4+3
   b) Immune check point inhibitors toxicities.
   c) Immune check point inhibitors in metastatic melanoma.
8. a) NGS and its utility in cancer management. 3+4+3
   b) Flow Cytometry in leukemia management.
   

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   c) Cytogenetics in cancer.

P.T.O.

9. a) Mutations in cancer pathogenesis. 3+4+3
   b) Tumor mutation burden.
   c) Role of MMR and MSI in cancer management.

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10. a) Image Guider Radiotherapy. 3+4+3
    b) Cyber Knife.
    c) Cobalt Radiotherapy.

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POSSESSION/USE OF CELL PHONES OR ANY SUCH ELECTRONIC GADGETS IS NOT PERMITTED INSIDE THE

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