Download JIPMER 2020 June Pathology Discussion

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Autophagy :
Unregulated catabolic process
Degradation of damaged proteins
Degradation of damaged proteins and organelles

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Anabolic process

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Autophagy
Chaperone-mediated autophagy (direct translocation
across the lysosomal membrane by chaperone proteins)
Microautophagy (inward invagination of lysosomal

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membrane for delivery)
Macroautophagy: major form : Involves sequestration and
transportation of portions of cytosol in a double membrane
bound autophagic vacuole (autophagosome)

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Role of Autophagy
Cancer
Neurodegenerative disorders: Alzhenmers and
Huntingtons dis
Infections: mycobacteria, Shigella and HSV-1.

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IBD

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Q
Pyrogenic mediators are all except?
IL 1
IL 6

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TGF ?
Ciliary Neurotropic factor

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Q
Not a cause for endometrial cancer
Infertility

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OCP
Tamoxifen

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Endometrial Carcinoma

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Q
Patient with Reticulocyte elevated and features of

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hepatitis with reduced hb . C/o abnormal behavior
and movements. MRI showed dense deposits in
basal ganglia. Likely diagnosis ?
Autoimmune hepatitis
Wilsons

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Thalassemia

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Stains

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Q
After one month of wound healing, type 3 is replaced with
type 1 in the ratio?

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1:6
2:5
1:3
8:3

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Q

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Type of necrosis seen in autopsy of post MI
patient?
Fibrinoid Necrosis
Coagulative Necrosis
Caseous Necrosis

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Liquefactive Necrosis

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Q
Ig expressed on surface of B cells
G
A

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M
E

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Q
In kidney transplant, which is Fully reversible once
established?

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Acute
Acute on chronic
Chronic
Hyperacute rejection

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Q
Steatorrhoea with acanthocytes?
Celiac disease
Whipples disease
Tropical sprue

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Abetalipoproteinemia

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Abetalipoproteinemia
Infants
Failure to thrive, diarrhea, vomiting, and fat
malabsorption.

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P/S: Acanthocytes with associated hemolytic anemia,
reticulocytosis, and raised bilirubin levels.
Malabsorption of fat-soluble vitamins such as Vit A, D, E,
and K results in the majority of the clinical
manifestations.

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Abetalipoproteinemia
Vit K deficiency: Raised INR and an increased risk of
bleeding.
Vit E deficiency: Neuromuscular symptoms such as
ataxia, muscle weakness, dysarthria, etc. usually manifest

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during the first or second decades of life.
Molecular genetic testing may be required to identify and
confirm mutations in the MTTP gene in these individuals.

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Q
Mendelian type of inheritance seen in which

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disease?
Downs with balanced translocation
Turner's with mosaicism
Huntington with trinucleotide repeats
Fragile X syndrome

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Q
Non-fluorescent is ?
Giemsa
Calcoflour
Auromine

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Acridine orange

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Q
26 yrs male with epiphysial bone tumor
shows lytic lesion with chicken-wire
calcification.

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Osteoblastoma
GCT
Chondroblastoma
....

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Q
Which condition has high reticulocyte
count ?
A)Aplastic anemia
B)Anemia of chronic disease

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C) iron deficiency anaemia
D)hemolytic anemia

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Q
A 80 year old woman . Forgetfulness in daily
activities. No seizures. Which of following is seen ?

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Neurofibrillary tangles

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Alzheimers disease

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Child with bilateral conjunctivitis. Fever
since 5 days and skin peeling present.

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Diagnosis?
Kawasaki disease
HSP
IgA nephropathy
Leptospirosis

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A child with hereditary renal disease, hematuria, proteinuria
with keratoconus with hearing loss diagnosis
Alports syndrome
IgA Nephropathy

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PSGN

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Alports syndrome

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Q
Glomerular pathology indicated by
Dysmorphic RBC

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Hyaline cast

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Q
Anti GQ 1b antibody not seen in:
Miller Fisher syndrome
Birkerstaff brainstem encephalitis

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Guillain Barre syndrome
Acute paresis of the ocular muscles.
Autoimmune disorder that causes eye muscle weakness.
This antibody interacts with the peripheral nerve
ganglioside, Gq1b.

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Q
Call exner body seen in :
Granulosa cell tumour
Yolk sac tumor
Teratoma

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Q
Which eyelid tumor doesn't spread through
lymphatic?
SCC
BCC

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Sebaceous Ca
Malignant Melanoma

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Q
Kleihauer?Betke test positive baby has
Hepatosplenomegaly. Diagnosis?

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Chronic fetomateral hemorrhage
Erythroblastosis foetalis
Spherocytosis
ABO incompatibilty

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A lady who had underwent radiotherapy few months back
for breast cancer came with bleeding gums. There was low
platelet low hb prolonged aptt, normal PT and past history
of preterm gestation.
APLA

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DIC
Radiation side effect
Hemophilia A

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Q
Complete hydatiform mole. karyotype?

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46,XX
69, XXY
69, XXX

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Q

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Sperm motility decreased in all except
Long drive
Running
Abstinence
Smoking

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Running a minimum mean distance of 108 km/week for 12 months
In particular, sperm motility peaked after one day abstinence in
men with infertility problems, but overall sperm quality began to
decline after two days of abstinence.
Among men with normal sperm, overall sperm quality peaked

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after seven days of abstinence and declined after 10 days

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Q
Which of the following has least risk of
cholangiocarcinoma
1. Primary biliary cirrhosis

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2. Primary Sclerosing Cholangitis
3. Chloronchis sinensis infestation
4. Choledochal cyst

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Q
A patient with road traffic accident came in shock. . Multiple units

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transfused. False statement is
Such types of blood transfusion are related to metabloic
complications.
Crystalloids can maintain hemodynamic stability
RBCs improve oxygen transport to tissue and increase

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hematocrit by 3%
Stored RBC has higher 2,3 DPG and shift to left

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Q
ANCA positive and Lupus antibodies positive
female and purple rash on face.

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SLE
APLA
Sjogrens

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Q
VNTR full-form?

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Variable Number Tandem Repeats
VNTR is a location in a genome where a short
nucleotide sequence is organized as a tandem repeat.
These can be found on many chromosomes, and often
show variations in length (number of repeats) among

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individuals.
RFLP genetic markers used in linkage analysis
Forensic crime investigations, via DNA fingerprinting
and the CODIS database

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Q

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Patient is in fever and shock. PT and PTTK both are elevated. FDP and D-
dimer raised. Diagnosis?
DIC
Aplastic anemia

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Q

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Cancer cachexia is associated with ?
Increased oxygen utilisation
TNF alpha

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Gene mutation associated with Pheochromocytoma
and Renal cell carcinoma is:

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VHL
Ataxia Telangiectasia
Bloom syndrome

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Bloom Syndrome
AR

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Short stature
Sun-sensitive, red rash that occurs primarily over the nose and
cheeks
Mild immune deficiency with increased susceptibility to infections
Insulin resistance that resembles type 2 diabetes

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Increased susceptibility to many types of cancer, especially
leukemia, lymphoma and gastrointestinal tract tumors.
Male infertillity

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