Download OU Pharm D Question Paper 3rd Sem 2018 1254 Medicinal Chemistry

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FACULTY OF PHARMACY

Pharm D (6-YDC) III - Year (Main & Backlog) Examination, June 2018

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Subject: Medicinal Chemistry

Time: 3 Hrs Max.Marks: 70

Note: Answer all questions from Part — A. Any Five questions from Part - B.

PART - A (10x2 = 20 Marks)

1. Define scabicide with example.

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2. Mention the type of hyperlipo proteinemia.
3. Give two examples with therapeutic use of polypeptide antibiotics.
4. Differentiate between disinfectant and antiseptic.
5. Write the chemical structure and uses of testosterone.
6. Define the term pro-drug and write application.

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7. What is combinatorial synthesis?
8. Write the structure mode of action of fluconazole.
9. Write the mode of action of cardiac glycoside.
10. Classify antihelmintic agents.

PART - B (50 Marks)

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11. a) Write the classification of anti-malarial agents with one example from each class. (10)
    b) Write synthesis, mode of action: (10)
    i) Cefalexine
    ii) Minocycline.
12. a) Write the S.A.R of cephalosporin and outline the synthesis of ampicillin. (10)
    

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    b) What are antiarrhythmic drugs? Classify them with examples, write the structure and uses of verapamil, phenytoin, and propranolol (10)
13. a) Write the S.A.R. of thiazide diuretic. (10)
    b) What are calcium channel blockers? Describe their effect on cardiovascular system. Write the synthesis of Warfarin. (10)
14. Write the synthesis, mode of action of following drugs: (10) i) Propylthiouracil
    ii) Mebendazole
    

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    iii) Clofibrate
    iv) Tolbutamide
15. a) Write the S.A.R of sulfonyl ureas. (10)
    b) Write the synthesis mode of action of: (10)
    i) Albendazole ii) Ketoconazole

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16. a) Write the classification of antiviral drug with one example of each class. (10)
    b) Write the synthesis, mode of action of: (10)
    i) Ethambutol ii) Isoniazid
17. Write short notes on: (10)
    i) Anti-inflammatory steroid ii) Endocrine hormone

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18. a) Classify antianginal agent with example. (10)
    b) Write the S.A.R of 7-chloro-4-amino quinoline. (10)

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