Download OU B.Pharma 2-1 Year 2013 7209 Pharmaceutical Analysis I Question Paper

Note: Answer all questions. All questions carry equal marks.

1. 1. i) What are primary and secondary standard substances? Give examples. 8

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   2. b) i) Define the terms :
      A) Specificity B) Sensitivity 4
      C) Linearity D) ruggedness
      ii) Explain the calibration of volumetric flask. 4
      iii) A substance was known to contain 15.20 + 0.03% of a component, A. The results obtained by two experiments taking the same substance and employing the same analytical method as follows : 6
      

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      Experiment—1 :%of A : 15.0, 15.31, 15.16 and 15.10
      Experiment—1Il : % of A : 15.30, 15.34, 15.36 and 15.36
      Discuss the results with reference to accuracy and precision of the measurements.
2. 1. i) Calculate the pH of a 0.01 M acetic acid. (Dissociation constant pKa = 4.76). 4
      

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      ii) Write a note on different concepts of acid and bases. 6
      iii) Write a note on common ion effect. 4

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   2. b) i) Derive equations to calculate the pH value of aqueous solutions of salts obtained from weak acid and strong base. 10
      ii) Write a note on amphoteric-substances by giving few examples. 4

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3. 1. i) Describe the various steps involved in gravimetric analysis. 10
      ii) How do you prepare and standardize 0.1 N sodium thiosulphate? 4

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   2. b) i) Explain in-detail about redox indicators. 7
      

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      ii) Explain Volhard’s method for the determination of chlorides. 7
4. 1. i) Write about different solvents and indicators used in non-aqueous titration. 7
      ii) Discuss the theory and applications of complexometric analysis with examples. 7

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   2. b) i) Explain Iodometry and Iodimetry with examples. 7
      ii) Write the principle and procedure involved in assay of calcium gluconate. 7
5. 1. i) Calculate the number of moles of sodium hydroxide in 500 ml. of 0.1 M sodium hydroxide solution: 4
      ii) Calculate the percentage composition of the elements in Na₂CO₃; [Na=23 , C=12,O=16]. 5
      

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      iii) 0.202 gm of a carbon compound on combustion gave 0.361 gm of CO₂ and 0.147 gm of water. Calculate the empirical formula of the compound. 5

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   2. b) i) Write the mass balance equation for the following : 2x3=6
      A) Reaction between ammonium hydroxide and sulphuric acid
      B) Reaction between sodium carbonate and hydrochloric acid
      

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      i) Calculate the percentage composition of the elements in Na₂S₂O₄ [Na=23,S=32,O=16]. 5
      iii) Calculate the molarity of 17 g of pure Na₂CO₃ in 600 ml. of solution. 3