Download OU B.Pharma 2-1 Year 2018 1170 Oranic Chemistry I Question Paper

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Time: 3 Hrs

CODE NO: 1170

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FACULTY

B. Pharmacy 2/4 | Semester (Suppl) Examination, April 2018

Subject: Pharmaceutical Organic Chemistry

Note: Answer All Questions. All Questions carry Equal Marks.

Max. Marks: 70

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1. 1. What is Hybridization? Discuss SP³, SP² and SP Hybridization with suitable examples
   2. Write a note on Electromeric effect and polarity of molecules

   OR

   1. What is activation energy? Explain the energy diagram of reactants and products during reaction
   2. Explain the terms with examples chirality and Hydrogen bonding

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2. 1. Define the terms configuration and conformation. Write the various conformations of cyclohexane and discuss their stability.
   2. Add a note on peroxide effect.

   OR

   1. Explain the Markovnikov's and anti-Markovnikov's addition with examples

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   2. Write the general methods to prepare the alkenes.
3. 1. Discuss in detail the mechanism and stereo chemistry involved in S_N1 and S_N2 reaction

   OR

   1. Add a note on Zeisel method or Williamson synthesis

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4. 1. How do you distinguish between primary, secondary and tertiary alcohols with different chemical reagents.
   2. Explain in detail the acidity of carboxylic acids with examples.

   OR

   1. Write any two methods for preparation of aldehydes and Ketones.

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   2. How do you synthesize the Schiff's bases
   3. Discuss any two Hydrophilic addition reactions of carbonyl compounds with mechanisms
5. 1. Write any two methods to synthesize secondary amines
   2. Give the mechanism for any two of the following reactions
      1. Sandmeyer reaction

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      2. Coupling reaction
      3. Gattermann reaction

   OR

   1. Give reactions of amines.

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   2. Write the synthesis and applications of aryl diazonium salts.