Download OU B.Pharma 3-1 Year 2014 8048 Medicinal Chemistry Question Paper

Download OU (Osmania University) B.Pharma 3-1 (3rd Year 1st Sem) (Bachelor of Pharmacy) 2014 8048 Medicinal Chemistry Previous Question Paper

PHARMACY
HYD
Code No. 8048
FACULTY OF PHARMACY
B.Pharmacy 3/4 I - Semester (Main) Examination, October/November 2014
Subject: Medicinal Chemistry  I
Time: 3 Hours Max. Marks: 70
Note: Answer all questions. All questions carry equal marks.
1 (a) Define and give its significance of following: (4 x 3)
(i) Ionization (ii) Surface activity (iii) Hydrogen bonding (iv) lipophilicity
(b) Give the applications of Bio-isosterism. (2)
OR
(c) Discuss in detail conjugation reactions involved in drug metabolism. (7)
(d) Write the importance of steric features of drugs. (7)
2 (a) Identity the following drug and give its structure and name. (8)
(i) Nitrite with vasodilator action
(ii) Iomidazole derivatives with anti-hypertensive action
(iii) Dihydropyridine derivative with anti arrhythmic action
(iv) Steroidal compound with positive Ionotropic action
(b) Write a note on HmG  CoA reuctase institutions. (6)
OR
(c) Give the structure, synthesis MOA and uses of following: (3 x 4)
(i) Ticlopidine (ii) Captopril (iii) Nefidipine
(d) How do you differentiate between cardienolides and Bufadinolides? (2)
3 (a) Explain the S.A.R. ofb -Adrenergic blocking agents. (6)
(b) Outline the synthesis mechanism of action (MoA) and uses of salbutamol and
mecamylamine HCl. (2 x 4)
OR
(c) Add a note on ganglionic blocking agents. (6)
(d) Give the structure, MoA and synthesis of isoproferenol and meprobamata. (2 x 4)
4 (a) Give the structure, synthesis and adverse effects of (4x3)
(i) Amrinone (ii) Hydro chlorthiazide (iii) furosemide (iv) Glyclazide
(b) Add a note on Anti-thyroidal agent. (2)
OR
(c) Discuss in detail structural activity relationship for Tolbutamide ring. (5)
(d) Give the structure, synthesis and MoA of following: (3 x 3)
(i) Acetazolamide (ii) Prophylthiouracil (iii) Amiloride
5 (a) Explain in detail S.A.R of H
1
 Anti histaminics. (10)
(b) Add a note on proton pump inhibitors. (4)
OR
(c) Give the structure synthesis and MoA of following: (3 x 4)
(i) Ranitidine (ii) Omeprazole (iii) Diphenhydramine
(d) List out the coagulation factors. (2)
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