Download OU B.Pharma 3-1 Year 2015 6048 Medicinal Chemistry I Question Paper

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Code No. 6048

FACULTY OF PHARMACY

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B. Pharmacy 3/4 I- Semester (Main) Examination, November 2015

Subject: Medicinal Chemistry - I

Time: 3 Hours Max.Marks: 70

Note: Answer All questions. All questions carry equal marks.

1. 1. Explain with examples the importance of bioisosterism in relation to biological activity. 7

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   2. What do you mean by soft drug approach in drug design? How is it achieved? 7

   OR

   1. Discuss with suitable examples the influence of protein binding on biological activity. 7
   2. Explain with examples the factors affecting the drug metabolism. 7

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2. 1. Classify adrenergic drugs with examples, write the mode of action, SAR and outline the synthesis of Atenolol. 2+3+5+4

   OR

   1. What are cholinergic drugs? Classify them with examples, discuss the mode of action, therapeutic uses and outline the synthesis of dicyclomine. 2+3+3+2+5
3. 1. What are antihypertensive agents? Classify them with examples, discuss the mode of action and SAR of ACE inhibitors. 2+3+3+3

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   2. Write the synthesis and specific uses of clonidine. 3

   OR

   1. What are anti-hyperlipidemic agents? Classify them with examples, write the mode of action and their SAR. 2+2+3
   2. Write the synthesis and uses of Clofibrate and Diltiazem. 3+4

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4. 1. What are diuretics? Classify them with examples, discuss the mode of action and SAR of thiazide diuretics. Outline the synthesis of Acetazolamide and Hydrochlorthiazide. 1+2+2+3+3+3

   OR

   1. Classify oral hypoglycemic agents with examples, write their mode of action, SAR and add a note on the current status of the management of NIDDM. Write the synthesis and uses of Glyclizide. 2+3+3+3+3
5. 1. Classify H1-receptor antagonists with examples, write the mode of action and SAR. Outline the synthesis and uses of Chlorpheniramine and Cetrizine. 3+2+3+3+3

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   OR

   1. Write a note on:
      1. Anticoagulants
      2. Proton-pump inhibitors.

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