Download OU B.Pharma 3-1 Year 2015 6048 Medicinal Chemistry I Question Paper

Download OU (Osmania University) B.Pharma 3-1 (3rd Year 1st Sem) (Bachelor of Pharmacy) 2015 6048 Medicinal Chemistry I Previous Question Paper

Pharmacy
OU - 1701 OU - 1701
Code No. 6048
FACULTY OF PHARMACY
B. Pharmacy 3/4 I ? Semester (Main) Examination, November 2015
Subject: Medicinal Chemistry ? I
Time: 3 Hours Max.Marks: 70
Note: Answer All questions. All questions carry equal marks.
1 a) Explain with examples the importance of bioisosterism in relation to biological
activity. 7
b) What do you mean by soft drug approach in drug design? How is it achieved? 7
OR
c) Discuss with suitable examples the influence of protein binding on biological
activity. 7
d) Explain with examples the factors affecting the drug metabolism. 7
2 a) Classify adrenergic drugs with examples, wite the mode of action, SAR and
outline the synthesis of Atenolol. 2+3+5+4
OR
b) What are cholinergic drugs? Classify them with examples, discuss the mode of
action, therapeutic uses and outline the synthesis of dicyclomine. 2+3+3+2+5
3 a) What are antihypertensive agents? Classify them with examples, discuss
the mode of action and SAR of ACE inhibitors. 2+3+3+3
b) Write the synthesis and specific uses of clonidine. 3
OR
c) What are anti-hyperlipidemic agents? Classify them with examples,
write the mode of action and their SAR. 2+2+3
d) Write the synthesis and uses of Clofibrate and Diltiazem. 3+4
4 a) What are diuretics? Classify them with examples, discuss the mode of
action and SAR of thiazide diuretics. Outline the synthesis of Acetazolamide
and Hydrochlorthiazide. 1+2+2+3+3+3
OR
b) Classify oral hypoglycemic agents with examples, write their mode of action, SAR
and add a note on the current status of the management of NIDDM. Write the
synthesis and uses of Glyclizide. 2+3+3+3+3
5 a) Classify H1-receptor antagonists with examples, write the mode of action and SAR.
Outline the synthesis and uses of Chlorpheniramine and Cetrizine. 3+2+3+3+3
OR
b) Write a note on:
i) Anticoagulants 7
ii) Proton-pump inhibitors. 7
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