Download OU (Osmania University) B.Pharma 3-1 (3rd Year 1st Sem) (Bachelor of Pharmacy) 2017 4223 Medicinal Chemistry I Previous Question Paper
Code No. 4223
FACULTY
B. Pharmacy 3/4 I Semester (Suppl.) Examination, April 2017
Subject : Medicinal Chemistry I
Time : 3 Hrs Max. Marks: 70
Note: Answer all questions. All questions carry equal marks.
1 (a) Explain the importance of Bioisosterism in dru desin. (7)
(b) Write abt phase I reactions of dru metabolism. (7)
OR
(c) Explain the importance of prodru and soft dru approa ch in dru desin. (7)
(d) How does plasma protein bnd dru effect bioloical activity. ive appropriate
examples. (7)
2 (a) Classify Anticholineric drus with one example each with structure and chemical
name. (5)
(b) ive the stru cture and synthesis of followin : (3x3)
(i) Salbutamol (ii) Dicyclomine (iii) Carbachol
OR
(c) Write the pharmacoloical actions of Adrenaline and discuss the SAR of
Adrenomimetics. (10)
(d) Write a note on skeletal muscle relaxants. (4)
3 (a) Write a note on diitalis lycosides. (4)
(b) Classify Anti hyper lipidemic aents with examples. (2)
(c) ive the structure, synthesis and MOA of clonidine and verapamil. (4+4)
OR
(d) Add a note on vasodilators. (5)
(e) Write the structure, synthesis and MOA of followin: (3x3)
(i) Clofibrate (ii) Captopril (iii) Isosorbide
4 (a) Add a note on immune modulators. (5)
(b) ive the classification of oral hypolycemic aents. Discuss the MoA and SAR
of Biu anides. ive the synthesis of Tolbutamide and Amrinone. (1+4+2+2)
OR
(c) Write abt Anti thyroidal aents. (7)
(d) ive a short note on positive ionotropic aents. (7)
5 (a) ive the SAR of any two classes of H1 ? Antihistamines. (5)
(b) Write the synthesis and MoA of fallowin : (3x3)
(i) Warfarin (ii) Ranitidine (iii) Citrizen
OR
(c) Add a note on proton pump inhibitors. (5)
(d) Write the synthesis and MoA of followin: (3x3)
(i) Omeprazole (ii) Diphenhydramine (iii) Chlorpheniramine
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This post was last modified on 04 May 2020