Download OU B.Pharma 3-1 Year 2019 13255NON CBCS Medicinal Chemistry I Question Paper

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Code No. 13255/Non CBCS

FACULTY OF PHARMACY

B. Pharmacy 3/4 | Semester (Non CBCS) (Backlog) Examination, July 2019

Subject : Medicinal Chemistry I

Time : 3 Hrs Max. Marks: 70

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Note: Answer All questions, All Questions carry equal marks.

1. 1. Explain the importance of bioisosters and steric features that are specific for elicitation of biologic response. 7M
   2. Write about protein binding of drugs, its advantages and disadvantages. 7M

   OR

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2. 1. Discuss in detail conjugation reactions involved in drug Metabolism. 6M
   2. Define and give the significance of ionization and partition coefficient. 8M
3. 1. What are cholinergic drugs. Write the MOA and SAR. 8M
   2. Give the structure and synthesis of following :
      1. Carbochol

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      2. Dicyclomine Hcl
      2x3=6M

   OR

4. Add a note on following:
   1. Adrenergic blocking agents 7M

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   2. Neuromuscular blocking agents. 7M
5. 1. What are anti-arrhythmic agents. Classify them with examples. Discuss the mode of action & SAR. 2+2+2+3M
   2. Write the synthesis and uses of captopril. 5M

   OR

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6. 1. Define and classify antihyperlipidemic agents with examples and SAR of statins. 7M
   2. Add a note on Vasodilators. 7M
7. 1. Write short note on Immuno-modulators. 6M

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   2. Give the synthesis and uses of Amiloride and Amrinone. 4+4M

   OR

8. 1. Write the structure, synthesis and uses of following drugs. 3.5x4=14M
      1. Propyl thiouracil
      2. Acetazolamide

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      3. Azathioprine
      4. Glyclazide
9. 1. Write a note on proton pump Inhibitors. 6M

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   2. Give the structure, synthesis, uses and MOA of omeprazole and cetirizine. 4+4M

   OR

10. 1. Add a note on coagulants and anti-coagulants. 6M
    2. Write the synthesis, MOA and uses of Diphenhydramine and warfarin. 8M

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