Pharm D Last 12 Years 2010-2022 Question Papers (1st Year, 2nd Year, 3rd Year, 4th Year and 5th Year)
[LB 823] OCTOBER 2012 Sub. Code: 3823
PHARM. D/ POST BACCALAUREATE DEGREE EXAMINATION
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FOURTH YEAR
PAPER V — BIOPHARMACEUTICS AND PHARMACOKINETICS
O.P. Code: 383823
Time: Three Hours Maximum: 100 marks
Answer ALL questions in the same order.
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I. Elaborate on :
| Pages (Max.) | Time (Max.) | Marks (Max.) | |
|---|---|---|---|
| 1. Discuss the principle that governs the renal excretion of drugs? | 17 | 40 min. | 20 |
| 2. Define Nonlinear Pharmacokinetics? What are the causes for the Nonlinearity? Explain Michaelis Menten equation with respect to the estimation of K, and V max? | 17 | 40 min. | 20 |
II. Write notes on :
| 1. Write a note on measurement of bioavailability by plasma Level - time study? | 4 | 10min. | 6 |
| 2. Discuss Latin square design in bioequivalent study? | 4 | 10min. | 6 |
| 3. Derive the equation for two compartment open model intravenous infusion? | 4 | 10min. | 6 |
| 4. How to determine the normal renal function in patients? | 4 | 10min. | 6 |
| 5. Write a note on statistical moment theory? | 4 | 10min. | 6 |
| 6. Calculate the absolute bioavailability of Amoxycillin capsule. The dose of the capsule was 500 mg and-the AUC was 50.9 mcghr/L. The dose of IV amoxyecillin is 250 mgand the AUC is 34.63 mcghr/L. | 4 | 10min. | 6 |
| 7. Write the importance of Wagner Nelson method in pharmacokinetics? | 4 | 10min. | 6 |
| 8. Write a note on Non Compartmental Pharmacokinetics | 4 | 10min. | 6 |
| 9. What are the formulation factors that affect drug absorption? | 4 | 10min. | 6 |
| 10. After oral administration of single dose of 500 mg rifampicin the following urine data were obtained. Calculate the renal excretion rate. | 4 | 10min. | 6 |
| Collection interval | Urine volume (ml) | Urine Concentration (mg/ml) |
|---|---|---|
| 0-2 | 119 | 0.60 |
| 2-4 | 81 | 0.70 |
| 4-8 | 160 | 0.50 |
| 8-12 | 220 | 0.23 |
| 12-18 | 284 | 0.15 |
| 18-24 | 212 | 0.10 |
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