PTU B-Pharma 4th Semester May 2019 46235 PHARMACEUTICS V Physical Pharmacy Question Paper

Total No. of Pages : 02

Roll No.

Total No. of Questions : 10

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B. Pharma (2011 to 2016) (Sem.-4)

PHARMACEUTICS-V

(Physical Pharmacy)

Subject Code : BPHM-405

M.Code: 46235

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Time: 3 Hrs.

Max. Marks : 80

INSTRUCTION TO CANDIDATES :

1. SECTION-A is COMPULSORY consisting of FIFTEEN questions carrying TWO marks each.
2. SECTION-B contains FIVE questions carrying FIVE marks each and students have to attempt any FOUR questions.

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3. SECTION-C contains FOUR questions carrying TEN marks each and students have to attempt any THREE questions.

SECTION-A

1. Answer briefly :
   1. What are the components of an aerosol system?
   2. What is an amorphous solid?
   3. Define particle volume.

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   4. Define loose and close packing of particles.
   5. What is meant by solubilization? Give two examples.
   6. Differentiate between Zeta and Nernst potential.
   7. What is plastic viscosity? Give one example.
   8. What is angle of repose and what does it indicate?

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   9. What is spreading coefficient?
   10. What are cage complexes?
   11. Give two examples of wetting agents.
   12. Mention the formulae for calculating half life of drugs following degradation by first order.
   13. Mention the Arrhenius equation and its utility.

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   14. What is contact angle?
   15. What is the HLB scale of hydrophobic surfactants?

SECTION-B

2. Define polymorphism with suitable examples. Briefly write about polymorphic behaviour of solids and its impact on forumations.

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3. What is the difference between work of cohesion and work of adhesion? How spreading coefficient is determined?
4. What is thixotropy and anti-thixotropy? Give examples and explain the use of these properties of polymers in dosage form design.
5. Enumerate and explain the methods used for determining particle volume.
6. Discuss the stability indicating parameters for emulsions.

SECTION-C

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7. Classify complexes with suitable examples. Comment on the advantages and disadvantages of complex formation in influencing drug stability and effectiveness.
8. Describe the difference between a deflocculated and flocculated suspension. Discuss the role of structured vehicles in formulating a physically stable suspension.
9. Distinguish between pseudoplastic and dilatant viscosities. Giving suitable examples explain their role in dosage form design.
10. Explain the need for eye drops to be isotonic with tears. Enumerate the methods employed for adjusting tonicity of eye drops. Discuss the sodium chloride equivalent method.

NOTE : Disclosure of Identity by writing Mobile No. or Making of passing request on any page of Answer Sheet will lead to UMC against the Student.

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