Download PTU M-Sc -Chemistry 3rd Semester May 2019 72626 MEDICINAL CHEMISTRY Question Paper

Download PTU (I. K. Gujral Punjab Technical University) MSc -Chemistry 3rd Semester May 2019 72626 MEDICINAL CHEMISTRY Question Paper.

1 | 72626 (S17)-1829

Roll No. Total No. of Pages : 02
Total No. of Questions : 09
M.Sc. (Chemistry) (2015 to 2017) (Sem.-3)
MEDICINAL CHEMISTRY
Subject Code : MSCH-312
M.Code : 72626
Time : 3 Hrs. Max. Marks : 100
INSTRUCTION TO CANDIDATES :
1. Attempt FIVE questions in ALL including question no. 1 which is COMPULSORY
and selecting ONE each from UNIT I to IV.

1. Write briefly :
a) What are Antibacterial agents?
b) Define HIV-protease inhibitors.
c) What are Cinchona alkaloids?
d) Give chemical structure of Sontoquine and Proguanil.
e) Define the terms Hypnotics and Sedatives.
f) What are Analeptics?
g) Explain tricyclic antidepressants.
h) Define Osmotic agents.
i) Give structure and uses of Furosemide.
(j) Define Endocrine Antagonists.
UNIT-I
2. a) Discuss in detail history and mechanism of antibacterial drugs. Add a note on
Fluoroquinolones.
b) What are Beta-lactams? Discuss in detail bacterial resistance against antibacterial
drugs.
3. a) What are antiviral agents? Discuss in detail DNA polymerase inhibitors.
b) Enumerate different targets for anti-HIV drugs. Discuss anti-HIV nucleosides.
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1 | 72626 (S17)-1829

Roll No. Total No. of Pages : 02
Total No. of Questions : 09
M.Sc. (Chemistry) (2015 to 2017) (Sem.-3)
MEDICINAL CHEMISTRY
Subject Code : MSCH-312
M.Code : 72626
Time : 3 Hrs. Max. Marks : 100
INSTRUCTION TO CANDIDATES :
1. Attempt FIVE questions in ALL including question no. 1 which is COMPULSORY
and selecting ONE each from UNIT I to IV.

1. Write briefly :
a) What are Antibacterial agents?
b) Define HIV-protease inhibitors.
c) What are Cinchona alkaloids?
d) Give chemical structure of Sontoquine and Proguanil.
e) Define the terms Hypnotics and Sedatives.
f) What are Analeptics?
g) Explain tricyclic antidepressants.
h) Define Osmotic agents.
i) Give structure and uses of Furosemide.
(j) Define Endocrine Antagonists.
UNIT-I
2. a) Discuss in detail history and mechanism of antibacterial drugs. Add a note on
Fluoroquinolones.
b) What are Beta-lactams? Discuss in detail bacterial resistance against antibacterial
drugs.
3. a) What are antiviral agents? Discuss in detail DNA polymerase inhibitors.
b) Enumerate different targets for anti-HIV drugs. Discuss anti-HIV nucleosides.
2 | 72626 (S17)-1829

UNIT-II
4. a) Define and classify Antimalarials. Discuss in detail 4-aminoquinolines and 8-
aminoquinolines.
b) Discuss in detail Sulphonamides and 9-aminoacridines.
5. a) What are Biguanides? Outline the synthesis of Chloroquine.
b) Discuss pyramidines and sulfones. Outline the commercial synthetic route to
Pyremethamine.
UNIT-III
6. a) Write a detailed note on Barbiturates. What are non-barbiturates?
b) Discuss Hydantoins and Benzodiazepines. Outline the synthesis Phenytoin.
7. a) Define and classify Anticonvulsants. Discuss in detail Glutetbimide and
Thenacemide.
b) What are Monoamine Oxidase Inhibitors? Outline the ayuthssisof Diazepam.
UNIT-IV
8. a) Explain Diuretics. Add a detailed note on Chlorothiazides and Analogs.
b) Discuss Sulfamoylebenzoic acid and analogs. Outline synthesis of Chorthalidone.
9. a) What are mercurials and acidifying salts? Outline synthesis of Ameloride and
Triameterene.
b) Discuss Benzothiadiazine and related compounds. Outline synthesis of
Hydrochlothiazide.


NOTE : Disclosure of Identity by writing Mobile No. or Making of passing request on any
page of Answer Sheet will lead to UMC against the Student.
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