Download SGBAU B-Pharma 2019 Summer 4th Sem Sem IV Medical Chemistry I New Question Paper

Download SGBAU (Sant Gadge Baba Amravati university) B.Pharma 2019 Summer (Bachelor of Pharmacy) 4th Sem Sem IV Medical Chemistry I New Previous Question Paper

B.Pharm. Fourth Semester (New)
Medical Chemistry - I : BP 402 T
Time:ThrecHours , aoeoon V MBLMnkaZ'I's
Notes : 1. Answer all question.
' 2. Illustrate your answer necessary with the help 'of neat sketches.
3. Discuss the reaction, mechanism wherever necessary.
4. Use of pen Blue/Bleck ink/re?ll only for Writing the answer book.
1. Multiple choice question. 20
i) ? If more the lipid / water partition coef?cient more will be ?-------
a) Water solubility b) Lipophilicity
c) Hydrophilicity ' (1) Both A & B
ii) Conjugation of a drug include the following except.
a) Glucunonidation ? b) Sulfate formation
c) Hydrolysis d) Methylation
iii) Which of the following drugs produce positive inotropic & negative chronotropic
action.
a) Dopamine b) Epinephrine
c) Digoxin d) Ispprcnaline
iv) Which of the following is selective alpha receptor antagonist.
a) Clonidine ~ b) Phentolamine
c) Prazosin . d) Yohimbine
v) One of the following is resistant to both true &?Pseudo cholinesterase enzyme.
a) Carbachol ? b) Ace?lcholinc
c) Methacholine d) Pilocarpinc
vi) An anti-cholinesterase which is used in Alzheimer?s disease is
a) Arecolin b) Donepezil
c) Isoproternol d) Physostigmine
vii) The neurotransmitter released at synaptic nerve vessels ?ber is
a) Epinephrine _ ? b) Nor-e?pinephpihe
c) Aoctylcholine ? d) Physostigmine
viii) Skeletal muscle relaxation produced by the drug -??- effectively antagonize by
neostigmine.
a) Diazepam b) Succinylcholine
c) Tubocurarine d) Aminophylliiie
ix) 1 Neuromuscular blocking agents a per action are
*a) Non-depolarizing blocking agent b) Depolaxjizing agent
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c) Both d) Nope of these
1 ' ' P.T.O

x) Substitution of alkyl on aryl group on position make the barbituric acid to act a
hypnotics.
a) C5 b) C4
c) (:2 d) C6
xi) Hypnotic benzodiazepines increase the period of time spent in the following.
a) Stage - II b) Stage - III
0) Stage ? IV d) Stage of REM
xii) Thioridazine havc common ,--.-..--- as a side effects.
a) Cardiac arrhythmias b) Interference with male sexual function
c) Both a & b (1) None of these
xiii) Huntington?s disease is mostly treated by -------
a) F lupenthixol b) Clozapine
c) Tri?uperidol d) Haloperidol
xiv) The COX-2 inhibiter is nor given if patient suffering or already taking.
a) Anti-allergic drug b) Anxiolytic drug
0) Antihypertensxve drug d) Anti-diabetic drug
xv) Isoenzyme pnmarily responsible for PUs production by cells involve in in?ammation.
3) COX ?1 b) COX?ll
c) Both a & b d) None of these
xvi) Following are the action of morphine except.
a) Respiratory centre depression b) Cough centre depression
0) Biliary colic d) Diarrhoea
xvii) The nature of morphine molecule is
a) Acidic b) Phenolic
c) Basic d) Neutral
xviii) Problem associated with nitrous oxide anaesthesia is
a) Behavioural problem b) Sensitizes the hea? to adrenaline
c) Prolonged dif?cult induction d) Tachycardia or arrhythmia occurs
xix) Ketamine is a
a) Short acting general anesthetic agents
b) Local Anesthetic agents
c) Antidepressivc agent
(1) Hypnotic agent
xx) Which of the following NSAID?S is a selective COX ? II inhibiter.
a) Piroxicam b) Indometacin
c) Celccoxib d) Diclofenac
Solve any two. 20
a) Discuss the conjugation reaction for Glucuronic anid & Glycine from phase ? II Drug
metabolism reaction. Why c?ochrome P ? 450 called cytochrome P ? 450?
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b)
C)
De?ne & classify Antipsychotic agent & explain any one drug from each class. Add
a note on SAR of Phenothiazine.
De?ne & classify sedative & Hypnotics drug write in detail about SAR of
Benzodiazepines.
Solve any seven.
8)
b)
C)
d)
8)
f)
g)
h)
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Write a note on partition coef?cient & Bioisostcrism.
Explain SAR of sympathomimetic Agents.
Explain Biosynthesis & catabolism of Acetyl choline.
Disduss phase - H drug metabolism via Acetylation & methylation.
Add a note on Cholinesterase reactivator.
Write a note on B blockers.
Explain any four drug from inhalationvanesthetics.
Add a note on Narcotic Antagonist.
Explain Phase ? I process of hydrolysis with cg.
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