Download SGBAU B-Pharma 2019 Summer 8th Sem Sem VIII Medicinal Chemistry IV Question Paper

Download SGBAU (Sant Gadge Baba Amravati university) B.Pharma 2019 Summer (Bachelor of Pharmacy) 8th Sem Sem VIII Medicinal Chemistry IV Previous Question Paper

P.Pages:1 MIN
Time : Three Hours l?y??wp 1m Max. Marks : 60
B..Pharm. Eighth Semester
35182 : Medicinal Chemistry - 1V : T-8.2
AW - 2326
Notes :
A11 question carry equal marks.
Answer ?ve question.
Discuss the reaction. mechanism wherever necessary.
Use of pen Blue/Black ink/re?ll only for writing the answer book.
Explain in detail rational drug design. Give its advantages over conventional drug design.
Lipophilicity, Shape and electron distribution have a major in?uence on drug activity.
Explain the parameters that are commonly used as measure of these properties in QSAR
approach to drug design.
What is QSAR? Explain Hansch analysis and Topliss decision tree methods in QSAR
approach to drug design.
W rite a detail account on structure based drug design with examples.
F xplain in detail concept of genetic engineering. Give its merits and demerits.
What do you understand by Design of ligand? Explain ligand design based on 3D
structure of receptor.
Wriie a note on any two.
a) Gene therapy.
b) Molecular mechanics.
0) Lead identi?cation.
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