Download SGBAU B-Pharma 2019 Summer 8th Sem Sem VIII Medicinal Chemistry IV Question Paper

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35182 : Medicinal Chemistry - IV : T-8.2

Pages : 1

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Time : Three Hours Max. Marks : 60

1. All questions carry equal marks.
2. Answer five questions.
3. Discuss the reaction, mechanism wherever necessary.
4. Use of pen Blue/Black ink/refill only for writing the answer book.

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1. Explain in detail rational drug design. Give its advantages over conventional drug design. 12
2. Lipophilicity, Shape and electron distribution have a major influence on drug activity. 12 Explain the parameters that are commonly used as measure of these properties in QSAR approach to drug design.
3. What is QSAR? Explain Hansch analysis and Topliss decision tree methods in QSAR approach to drug design. 12
4. Write a detail account on structure based drug design with examples. 12
5. Explain in detail concept of genetic engineering. Give its merits and demerits. 12

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6. What do you understand by Design of ligand? Explain ligand design based on 3D structure of receptor. 12
7. Write a note on any two. 12
   1. Gene therapy.
   2. Molecular mechanics.
   3. Lead identification.

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