Download RTMNU B.Pharma 5th Semester 2016 Summer Pharmaceutical Medicinal Chemistry 1 Question Paper

Download RTMNU (Rashtrasant Tukadoji Maharaj Nagpur University) B.Pharma (Bachelor of Pharmacy) 5th Semester 2016 Summer Pharmaceutical Medicinal Chemistry 1 Question Paper

TKN/KS/16?6994
Fifth Semester Examination for the Degree
01? Bachelor of Pharmacy
PHARMACEUTICAL MEDICINAL CHEMISTRY ? I
5T2
Time : Three Hours ] [ Max. Marks : 80
N. B. : (1) Question No. 1 is compulsory.
(2) Solve any four questions from the remaining.
(3) Draw neat labelled diagram wherever necessary.
1. Solve any ?ve of the following :?
(A) Draw structure, IUPAC Name, uses and synthesis
of Phenytoin.
(B) Justify, why Carbidopa is given in combination with
Levodopa.
(C) Discuss role of phosphodiesterase inhibitors.
(D) Justify 5, S ? disubstituted barbiturates shows
sedative and hypnotic activity.
(E) How solubility affects absorption and distribution of
drugs ?
(F). Draw structure, IUPAC name, uses and synthesis of
Aspirin.
(G) What are Autocoids ? Explain in brief.
5 X 4 = 20
2. Describe phase I and Phase 11 reactions with examples.
15
TKN/KS/16?6994 Contd.
5??
(A) Define and classify Sedative and Hypnotics. Write
mode of action and synthesis of one drug from
Benzodiazepine class. 10
(B) Write note on antiepileptic agents. 5
4. What are Narcotic analgerics and classify them ? Explain
SAR of any one class of opioid Analgesics. Write synthesis
of any one drug. 15
5. Classify Local anesthetics ? Discuss SAR, metabolism and
synthesis of Lidocaine. 15
6. (A) De?ne and classify Antipsychotics. 7
(B) Write structure, IUPAC names synthesis and uses
of any two H ? 1 antagonists. 8
7. Write notes on (any three) of the following :?
(a) Receptor site theory
(b) Hypoglycaemic agents
(c) Alzheimer?s disease
((1) Thyroid and anti ? thyroid Harmones
(e) Bronchodilators. 5X3= 15
TKN/KS/16?6994 2 430