Download RTMNU B.Pharma 5th Semester 2017 Winter Pharmaceutical Medicinal Chemistry 1 Question Paper

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Time : Three Hours] [Maximum Marks : 80

N.B. :- (1) Question No. 1 is compulsory.

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(2) Attempt any four questions out of remaining.

(3) Discuss the reaction, mechanism wherever necessary.

NRJ/KW/17/4280

B.Pharm Examination

PHARMACEUTICAL MEDICINAL CHEMISTRY-I

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Paper-2

1. Attempt any five of the following : 5×4=20
   1. Write Chemical name, use and synthesis of phenobarbitone.
   2. Discuss about blood brain barrier.
   3. Write note on drugs used in treatment of Alzheimer's disease.
   4. Explain in detail about oxytocics.

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   5. Enlist different physicochemical parameters affecting drug action. Explain any one of them.
   6. Write Chemical name, use and synthesis of tolbutamide.
   7. Write note on CNS stimulant agents.
2. What is Asthma ? Classify chemically antiasthmatic agents. Give synthesis of any one drug and write briefly on antitussive and decongestant. 15

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3. 1. Discuss about thyroid hormones and antithyroid drugs. 7
   2. Explain chemistry of hypoglycemic agents with examples. 8
4. What are different biological factors affecting drug metabolism ? Write in detail about functionalisation and conjugation reactions with different examples. 15
5. What are NSAID's ? Explain salol principle with examples. Write in detail chemical classification of NSAID's giving synthesis and uses of Ibuprofen. 15

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6. 1. What is convulsion ? Write chemistry of anticonvulsant agents with suitable examples. 8
   2. Write note on prostaglandins and eicosanoids. 7
7. Write notes on any three of following 3×5=15
   1. Principles of prodrug design
   2. Drugs used in Parkinsonism

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   3. Antidepressants
   4. Local anaesthetics.

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