Download RTMNU (Rashtrasant Tukadoji Maharaj Nagpur University) B.Pharma (Bachelor of Pharmacy) 5th Semester 2017 Winter Pharmaceutical Medicinal Chemistry 1 Question Paper
B.Pharm Fifth Semester (C.B.S.) Examination
PHARMACEUTICAL MEDICINAL CHEMISTRY?I
Paper?Z
Time : Three Hours] [Maximum Marks : 80
NB. :? (1) Question No. 1 is compulsory.
(2) Attempt any four questions out of remaining.
(3) Discuss the reaction, mechanism wherever necessary.
1. Attempt any ?ve of the following :
(a) Write Chemical name, use and synthesis of phenobarbitone.
(b) Discuss about blood brain barrier.
(c) Write note on drugs used in treatment of Alzheimer?s disease.
((1) Explain in detail about oxytocics.
(e) Enlist different physicochemical parameters affecting drug action. Explain any one of them.
(1) Write Chemical name, use and synthesis of tolbutamide.
(g) Write note on CNS stimulant agents. 5X4=20
2. What is Asthma ? Classify chemically antiasthmatic agents. Give synthesis of any one drug and write
brie?y on antitussive and decongestant. 15
3. (a) Discuss about thyroid honnones and antithyroid drugs. 7
(b) Explain chemistry of hypoglycemic agents with examples. 8
4. What are different biological factors affecting drug metabolism ? Write in detail about functionalisation
and conjugation reactions with different examples. 15
5. What are NSAID?S ? Explain salol principle with examples. Write in detail chemical classi?cation of
NSAID?s giving synthesis and uses of Ibuprofen. 15
6. (a) What is convulsion ? Write chemistry of anticonvulsant agents with suitable examples. 8
(b) Write note on prostaglandins and eicosanoids. 7
7. Write notes on any three of following :
(a) Principles of prodrug design and applications
(b) Drugs used in Parkinsonism
(c) Antidepressants
((1) Local anaesthetics. 3X5=15
POY?27553
This post was last modified on 19 January 2020