Download RTMNU B.Pharma 6th Semester 2016 Winter Pharmaceutical Medicinal Chemistry 2 Question Paper

FirstRanker's choice

FirstRanker.com

KNT/KW/16/6571

--- Content provided by FirstRanker.com ---

B.Pharm. Sixth Semester (C.B.S.) Examination

PHARMACEUTICAL MEDICINAL CHEMISTRY—II

Paper-2 (6T2)

Time : Three Hours]

[Full Marks : 80

--- Content provided by FirstRanker.com ---

N.B. :— (1) Question No. 1 is compulsory.

(2) Solve any FOUR questions from the remaining.

(3) Draw neat labelled diagram wherever necessary.

(4) Discuss the reaction, mechanism wherever necessary.

(5) Use of electronic calculator is permitted

--- Content provided by FirstRanker.com ---

(6) Assume suitable data wherever necessary

1. Solve any FOUR questions of the following :
   1. Major limitation of sulfonamides is crystalluria. What are the different ways to overcome this limitation?
   2. Explain chemistry and uses of polypeptide antibiotics.
   3. Write a brief note on computer aided drug design.
   4. Write chemical structure, name, synthesis and uses of chloramphenicol.

   --- Content provided by FirstRanker.com ---

   5. Explain the role of various plant products as anticancer therapy. 4×5=20
2. (a) Write detailed classification of antimalarial drugs with examples, chemical structures and mechanism of action. 10
   (b) What is amebiasis ? Write medicinal chemistry of drug therapy used in amebiasis. 5
3. Give life cycle of virus. What are the different drugs acting at various stages of virus life cycle ? 15

--- Content provided by FirstRanker.com ---

4. Write classification of β-lactam antibiotics and discuss its chemistry and uses. 15
5. (a) Describe structure activity relationship of tetracyclines. 8
   (b) Give the various drugs of azole chemical class having antifungal activity. 7
6. (a) What is quantitative structure activity relationship? Give its significance in drug design. 6
   (b) Classify the alkylating agents with chemical structures. 9

--- Content provided by FirstRanker.com ---

7. Write notes on any THREE of the following :
   1. Anthelmentics
   2. Importance of combinatorial chemistry
   3. Introduction to genetic engineering
   4. Theoretical consideration of quantitative structure activity relationship. 15

--- Content provided by FirstRanker.com ---