This download link is referred from the post: RTMNU B-Pharm Last 10 Years 2010-2020 Previous Question Papers || Rashtrasant Tukadoji Maharaj Nagpur University
NRJ/KW/17/4296
B.Pharm. Examination
BIOPHARMACEUTICS AND PHARMACOKINETICS
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Paper-6
[Maximum Marks : 80
Time: Three Hours]
N.B. :— (1) Question No. 1 is compulsory.
(2) Attempt any four questions out of remaining.
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(3) Draw neat labelled diagrams wherever necessary.
- Solve any five questions : 5×4=20
- What are the various causes of nonlinearity of drugs ?
- Explain any four factors affecting gastric emptying in drug absorption.
- What are the characteristics of microsomal enzymes ?
- Comment on ABC transporters.
- Define and explain absolute and relative bioavailability.
- Comment on biliary excretion of drugs.
- Explain in-vitro in vivo correlation in brief.
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- (a) Discuss in detail physicochemical factors affecting drug absorption. 8
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(b) Enlist non oral routes of drug absorption. Write about nasal and parenteral route of drug absorption in detail. 7 - (a) Discuss physiological barriers for distribution of drugs. 8
(b) Comment on plasma-protein binding of drugs. Explain significance of drug-protein binding. 7 - (a) Explain mechanisms of renal drug excretion. 8
(b) Define renal clearance and add a note on concept of clearance. 7 - (a) Define bioavailability and bioequivalence. Enlist methods for measurement of bioavailability. Discuss pharmacokinetic method in detail. 8
(b) Comment on theories of dissolution. 7 - (a) Elucidate pharmacokinetic parameters for one compartment open model after intravenous bolus administration. 8
(b) Discuss glucuronidation biotransformation reactions with examples. 7 - Write short notes on (any two) : 7.5×2=15
- Study designs for bioequivalence testing
- USP dissolution testing apparatus
- Passive diffusion of drugs
- Volume of distribution.
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POY-27563
This download link is referred from the post: RTMNU B-Pharm Last 10 Years 2010-2020 Previous Question Papers || Rashtrasant Tukadoji Maharaj Nagpur University
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