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Download RTMNU B.Pharma 7th Semester 2017 Winter Biopharmaceutics and Pharmacokinetics Question Paper

Download RTMNU (Rashtrasant Tukadoji Maharaj Nagpur University) B.Pharma (Bachelor of Pharmacy) 7th Semester 2017 Winter Biopharmaceutics and Pharmacokinetics Question Paper

This post was last modified on 19 January 2020

This download link is referred from the post: RTMNU B-Pharm Last 10 Years 2010-2020 Previous Question Papers || Rashtrasant Tukadoji Maharaj Nagpur University


NRJ/KW/17/4296

B.Pharm. Examination

BIOPHARMACEUTICS AND PHARMACOKINETICS

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Paper-6

[Maximum Marks : 80

Time: Three Hours]

N.B. :— (1) Question No. 1 is compulsory.

(2) Attempt any four questions out of remaining.

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(3) Draw neat labelled diagrams wherever necessary.

  1. Solve any five questions : 5×4=20
    1. What are the various causes of nonlinearity of drugs ?
    2. Explain any four factors affecting gastric emptying in drug absorption.
    3. What are the characteristics of microsomal enzymes ?
    4. Comment on ABC transporters.
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    6. Define and explain absolute and relative bioavailability.
    7. Comment on biliary excretion of drugs.
    8. Explain in-vitro in vivo correlation in brief.
  2. (a) Discuss in detail physicochemical factors affecting drug absorption. 8

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    (b) Enlist non oral routes of drug absorption. Write about nasal and parenteral route of drug absorption in detail. 7
  3. (a) Discuss physiological barriers for distribution of drugs. 8
    (b) Comment on plasma-protein binding of drugs. Explain significance of drug-protein binding. 7
  4. (a) Explain mechanisms of renal drug excretion. 8
    (b) Define renal clearance and add a note on concept of clearance. 7
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  6. (a) Define bioavailability and bioequivalence. Enlist methods for measurement of bioavailability. Discuss pharmacokinetic method in detail. 8
    (b) Comment on theories of dissolution. 7
  7. (a) Elucidate pharmacokinetic parameters for one compartment open model after intravenous bolus administration. 8
    (b) Discuss glucuronidation biotransformation reactions with examples. 7
  8. Write short notes on (any two) : 7.5×2=15
    1. Study designs for bioequivalence testing
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    3. USP dissolution testing apparatus
    4. Passive diffusion of drugs
    5. Volume of distribution.

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POY-27563



This download link is referred from the post: RTMNU B-Pharm Last 10 Years 2010-2020 Previous Question Papers || Rashtrasant Tukadoji Maharaj Nagpur University

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