Download RTMNU B.Pharma 7th Semester 2017 Winter Biopharmaceutics and Pharmacokinetics Question Paper

Download RTMNU (Rashtrasant Tukadoji Maharaj Nagpur University) B.Pharma (Bachelor of Pharmacy) 7th Semester 2017 Winter Biopharmaceutics and Pharmacokinetics Question Paper

Time :
NRJ/KW/17/4296
B.Pharm. Seventh Semester (C.B.S.) Examination
BIOPHARMACEUTICS AND PHARMACOKINETICS
Paper?6
Three Hours] [Maximum Marks : 80
NB. :? (1) Question N0. 1 is compulsory.
(2) Attempt any four questions out of remaining.
(3) Draw neat labelled diagrams wherever necessary.
1. Solve any ?ve questions :
(a)
(b)
(c)
(d)
(e)
(f)
(g)
2. (a)
(b)
3. (a)
(b)
4. (a)
(b)
5. (a)
(b)
6. (a)
(b)
What are the various causes of nonlinearity of drugs ?
Explain any four factors affecting gastric emptying in drug absorption.
What are the characteristics of microsomal enzymes ?
Comment on ABC transporters.
De?ne and explain absolute and relative bioavailability.
Comment on biliary excretion of drugs.
Explain in-Vitro ? in Vivo correlation in brief 5X4=20
Discuss in detail physicochemical factors affecting drug absorption. 8
Enlist non oral routes of drug absorption. Write about nasal and parenteral route of drug
absorption in detail. 7
Discuss physiological barriers for distribution of drugs. 8
Comment on plasma?protein binding of drugs. Explain signi?cance of drug?protein binding.
7
Explain mechanisms of renal drug excretion. 8
De?ne renal clearance and add a note on concept of clearance. 7
De?ne bioavailability and bioequivalence. Enlist methods for measurement of bioavailability.
Discuss pharmacokinetic method in detail. 8
Comment on theories of dissolution. 7
Elucidate pharmacokinetic parameters for one compartment open model after intravenous
bolus administration. 8
Discuss glucuronidation biotransformation reactions with examples. 7
7. Write short notes on (any two) :
(a)
(b)
(C)
((0
Study designs for bioequivalence testing
USP dissolution testing apparatus
Passive diffusion of drugs
Volume of distribution. 7.5X2=15
POY?27563