Download RTMNU B.Pharma 7th Semester 2017 Winter Biopharmaceutics and Pharmacokinetics Question Paper

NRJ/KW/17/4296

B.Pharm. Examination

BIOPHARMACEUTICS AND PHARMACOKINETICS

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Paper-6

[Maximum Marks : 80

Time: Three Hours]

N.B. :— (1) Question No. 1 is compulsory.

(2) Attempt any four questions out of remaining.

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(3) Draw neat labelled diagrams wherever necessary.

1. Solve any five questions : 5×4=20
   1. What are the various causes of nonlinearity of drugs ?
   2. Explain any four factors affecting gastric emptying in drug absorption.
   3. What are the characteristics of microsomal enzymes ?
   4. Comment on ABC transporters.

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   5. Define and explain absolute and relative bioavailability.
   6. Comment on biliary excretion of drugs.
   7. Explain in-vitro in vivo correlation in brief.
2. (a) Discuss in detail physicochemical factors affecting drug absorption. 8
   

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   (b) Enlist non oral routes of drug absorption. Write about nasal and parenteral route of drug absorption in detail. 7
3. (a) Discuss physiological barriers for distribution of drugs. 8
   (b) Comment on plasma-protein binding of drugs. Explain significance of drug-protein binding. 7
4. (a) Explain mechanisms of renal drug excretion. 8
   (b) Define renal clearance and add a note on concept of clearance. 7

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5. (a) Define bioavailability and bioequivalence. Enlist methods for measurement of bioavailability. Discuss pharmacokinetic method in detail. 8
   (b) Comment on theories of dissolution. 7
6. (a) Elucidate pharmacokinetic parameters for one compartment open model after intravenous bolus administration. 8
   (b) Discuss glucuronidation biotransformation reactions with examples. 7
7. Write short notes on (any two) : 7.5×2=15
   1. Study designs for bioequivalence testing

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   2. USP dissolution testing apparatus
   3. Passive diffusion of drugs
   4. Volume of distribution.

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POY-27563