Download RTMNU B.Pharma 2nd Semester 2016 Winter Pharmaceutical Chemistry 2 (Organic) Question Paper

B.Pharm. (Second Semester) (C.B.S.) Examination

PHARMACEUTICAL CHEMISTRY—II (Organic)

Paper-2 (2 T 2)

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Time : Three Hours]                                                                                                                  [Full Marks: 80

N.B. :— (1) Question No. 1 is compulsory.

(2) Solve any FOUR questions from the remaining.

(3) Draw neat labelled diagram wherever necessary.

(4) Discuss the reaction, mechanism wherever necessary.

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(5) Use of electronic calculator is permitted.

1. Solve any FIVE of the following : 5×4=20
   1. Define stereoisomers giving examples.
   2. Give sources of organic compounds with examples.
   3. Explain various intermolecular forces.
   4. Why chair conformation is more stable than the boat conformation in cyclohexane ?

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   5. What is hybrid orbital ? Explain hybridisation.
   6. Write the principle involved in detection and estimation of elemental nitrogen in organic compounds.
   7. Melting point of inorganic compounds is more than that of organic compounds.
2. (a) Write in detail about the Kjeldahl's method of Nitrogen estimation. 7
   

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   (b) What are racemic mixtures ? Explain various methods of resolution of racemic mixtures. 8
3. (a) Define the term functional group. Enlist the various functional groups present in the organic compounds and write in brief about the types of organic reactions. 7
   (b) Define the term empirical formula and molecular formula. Give the various rules for calculating the empirical formula. 3
   (c) A qualitative analysis of papaverine, one of the alkaloids in opium showed carbon, hydrogen and nitrogen. A qualitative analysis gave 70.8% carbon, 6.2% hydrogen and 4.1% nitrogen. Calculate the empirical formula of papaverine. 5
4. (a) Define the term conformation. Write in detail about the conformation of n-butane with energy profile diagram. 7
   

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   (b) Justify the following statements :
   (i) Trans-isomers are more stable than cis isomers.
   (ii) Salicylic acid is stronger than p-hydroxy benzoic acid. 8
5. (a) Give brief account on hydrogen bonding and explain its effect on aqueous solubility and bond lengths. 8
   (b) What is an orbital ? Give an account on atomic orbital and molecular orbital theory. 7

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6. (a) Write in detail about the structure of cyclohexane and the conformation of substituted cyclohexane. 7
   (b) Give the IUPAC name of the following :
   (i) ? H-? ? ? ?-? HHOH H
   (ii) H3C – C – C = CH
   CH3
   

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   CH3
   (iii) CH3-C – CH3
   
   OH
   (c) Write short note on Bayer's Strain theory. 4

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7. (a) Define and classify alcohols with suitable examples. How will you differentiate primary, secondary and tertiary alcohols. 7
   (b) Draw structure of the following compounds :
   (i) 1, 2-Dibromopropane
   (ii) 3-methyl octane
   (iii) 2, 2-dimethyl butanoic acid
   

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   (iv) ß-naphthol.
   (c) Write a note on sequence rule. 4

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