Download RTMNU B.Pharma 3rd Semester 2016 Winter Pharmacology 1 Question Paper

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B.Pharm. Third Semester (C.B.S.) Examination

PHARMACOLOGY—І

Paper-4 (3T4)

[Full Marks : 80

Time : Three Hours]

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N.B. :— (1) Question No. 1 is compulsory.

(2) Solve any FOUR questions from the remaining.

(3) Draw neat labeled diagram wherever necessary.

1. Solve any five : 5×4=20
   1. Explain significance of blood brain barrier.
   2. Write principle and methodology of digitalis bioassay.

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   3. Write significance of subcutaneous route of drug administration with suitable examples.
   4. Differentiate competitive and non competitive antagonism with suitable examples.
   5. Describe various factors modifying drug action.
   6. Explain biotransformation of drugs with suitable examples.
   7. Describe partial agonist and inverse agonist with suitable examples.

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2. Explain signal transduction mechanism. Add a note on secondary messenger system of G-protein coupled receptors. 15
3. Discuss in detail various factors affecting absorption of drug across gastro-entestinal trout. Add a note on first pass metabolism. 15
4. Describe different types of route of drug administration. Describe various parenteral routes with their merits and demerits. 15
5. Describe different types of adrenergic receptor along with its location and physiological significance. Add a note on various adrenergic agonists used clinically. 15

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6. Describe in detail pharmacological profile of different Anti-muscarnic agents with specific clinical indications. Add a note on treatment of organophosphate poisoning. 15
7. Write short notes on any three of the following : 3×5=15
   1. Mechanism of action and clinical indications of ganglionic blocks.
   2. β-adrenergic antagonists
   3. Neuromuscular blocking agents
   4. Bio-assay of insulin.

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