Download RTMNU B.Pharma 3rd Semester 2017 Summer Pharmacology 1 Question Paper

NKT/KS/17/6555

B.Pharm. Semester—III (C.B.S.) Examination

PHARMACOLOGY-I

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Paper-4

Note :- (1) Question No. 1 is compulsory.

(2) Solve any four questions from the remaining.

(3) Draw neat labelled diagrams wherever necessary.

[Maximum Marks : 80

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1. Solve any five :

   1. Compare the pharmacological profile of neostigmine and physostigmine.
   2. Explain the significance of plasma protein binding with suitable examples.
   3. Write principle and methodology of insulin bioassay.
   4. Describe the symptoms and treatment of myastania gravis.

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   5. Justify the use of adrenergic agonists in the treatment of bronchial asthma.
   6. What is log-dose response curve ? Explain its significance.
   7. Write a brief note on nuclear receptors.

   5×4=20

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2. Give classification of anti-cholinergic agents. Explain pharmacological profile, clinical indication and adverse effect of anti-muscarinic agent.

   15

3. Explain mechanism of action, pharmacokinetic adverse effects, contraindication and therapeutic uses of propranolol.

   15

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4. Explain different routes of drug administration along with advantages and drawbacks. Add a note on Enema.

   15

5. What is first pass metabolism ? Explain in detail various phases of drug metabolism. Add a note on microsomal enzyme induction and inhibition.

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   15

6. Give classification and explain mechanism of action, pharmacokinetic, adverse effects and clinical indications of Anti-cholinesterases agents.

   15

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7. Write short notes on the following (any three) :

   1. Neuromuscular stimulant drugs
   2. Excretion of drugs
   3. Factors affecting drug absorption
   4. Principle and design of digitalis bio-assay.

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   3×5=15

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