Download OU M.Pharma Pharmaceutics 1st Sem 2018 1291PCI Modern Pharmaceutics Question Paper

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FACULTY OF PHARMACY

M. Pharmacy (Pharmaceutics) I-Semester (PCI) (Suppl.) Examination, August 2018

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Subject: Modern Pharmaceutics

Time: 3 Hrs Max. Marks: 75

Note: Answer any five questions. All questions carry equal marks.

1. 1. Explain the methods for testing of drug excipient compatability studies.
   2. Describe the preparation of SMEDDS and their evaluation tests.

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   3. Define factorial design. Describe the applications and limitations.
2. 1. Discuss the ICH guidelines for calibration and validation of equipment with an example. (8 Marks)
   2. Describe the validation of tableting process. (7 Marks)

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3. 1. Discuss the sales forecasting and budget planning in pharmaceutical industries. (8 Marks)
   2. Describe the layout of buildings, services, equipment and their maintenance in industries. (7 Marks)
4. 1. What is compaction profile? Explain the phases of compaction profile with suitable examples. (5 Marks)
   2. Define the term intrinsic solubility. How to determine it? What is its significance? (5 Marks)

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   3. Explain the properties of granules effecting the compression behavior of tablets. (5 Marks)
5. 1. Discuss the pharmacokinetic parameters for determination of bioavailability. (5 Marks)
   2. Describe the comparison of dissolution profiles of dosage forms using similarity and difference factors.
   3. Explain the variance and standard deviation with its significance.

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6. 1. Describe the methods of evaluation of physical stability of emulsions.
   2. Describe the sterilization procedures for evaluation of parenterals.
   3. Describe the chi-square distribution.

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7. 1. Write the methods for determination of the order of a reaction.
   2. Explain the photo degradation and its testing procedure.
8. 1. Discuss the methods for improvement of aqueous solubility of drugs.
   2. Write Heckle equation and draw Heckle plots for porosity and explain them.

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