Download OU M.Pharma Ph.Chemistry 2nd Sem 2020 6113PCI Advanced Spectral Analysis Question Paper

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Code No. 6113/PCI

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FACULTY OF PHARMACY

M. Pharmacy (Pharmaceutical Chemistry) II-Semester (PCII) (Suppl.) Examination, January 2020

Subject: Advanced Spectral Analysis

Time: 3 Hrs Max. Marks: 75

Note: Answer any five questions. All questions carry equal marks.

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1. (a) Explain Woodward Fieser rules for a, ß-carbonyl compounds and 1,3-butadienes and calculate the ? max for the following. i) ii) iii) (b) How do you interpret the following functional groups in IR (i)-OH (ii) Ar-NH₂ (iii) -C=O (iv)—COOH (v)-CN (vi)-Cl ? (9+6)
2. Draw schematic 1-D & 2-D NMR spectra and explain the interpretation giving one example. (15)
3. (a) Discuss the fragmentation pattern of various functional groups. (8) (b) Explain Mc-Lefferty rearrangement and isotopic peaks. (7)
4. Explain the Principle, instrumentation and applications of following : (a) HPLC (b) GC-MS (8+7)
5. (a) Explain the Principle, instrumentation and applications of LCMS. (b) Write a note on super critical chromatography. (10+5)

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6. Explain the Principle instrumentation and applications of : (7+8) (a) DSC (b) TGA
7. (a) Explain the bio assay of insulin (b) Write a note on Radioimmunoassay (8+7)
8. Draw and explain the proton NMR and Mass spectra of Benzyl alcohol and 4-hydroxy toluene (15)

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