Download VNSGU MBBS 2010 2nd Year R 1569 Pharmacology Paper I Question Paper

R-1569

Second Year M. B. B. S. Examination

February - 2010

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Pharmacology : Paper - I

Time : Hours] [Total Marks: 40

Instructions :

1. Fill up strictly the details of signs on your answer book.

Name of the Examination:

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S. Y. M. B. B. S.

Name of the Subject:

Pharmacology - 1

2. Figures at right indicate marks.
3. Answers should be brief and to the point.

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4. Give suitable examples where needed.
5. Draw diagrams if necessary.

1 Answer the following: 9

1. What is double blind study in a clinical trial?
2. Name 2 (two) drugs that block the axonal uptake of noradrenaline.

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3. What are prodrugs? Explain giving one example.
4. Why is tropicamide preferred over atropine for fundoscopy?
5. Nasal decongestants should not be used for long periods. Give reason.
6. Enalapril may cause dry cough as an adverse reaction. The same is not seen with Losartan. Why?
7. Why is it preferable to use corticosteroids by inhalation rather than oral route in chronic bronchial asthma?

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8. What is Monday Morning sickness?
9. What is orphan drug? Give one example.

R-1569] 1 [Contd...

2 Answer any three of the following: 9

1. Explain with suitable examples how change in pH of urine is helpful in therapeutics. Mention drugs used to alkalinize urine.

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2. Enumerate various antiplatelet drugs. Discuss therapeutic uses of these agents in relation to cardiovascular system with pharmacological basis.
3. What is paradoxical tachycardia produced by quinidine? How can it be prevented? - Explain.
4. Compare and contrast properties of succinylcholine and d-tubocurarine (d-tz).
5. Enumerate various indications of heparin. How will you monitor the anticoagulant therapy?

3 Answer any three of the following : 12

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1. Enlist various ACE Inhibitors. Discuss the clinical uses and adverse effects of ACE Inhibitors.
2. Discuss the role of cardiac glycosides in a patient with congestive cardiac failure.
3. Discuss Oral Rehydration Therapy in Management of diarrhoea.
4. What is DRC? Explain competitive and non competitive antagonism. Give two examples each of competitive and non competitive antagonism.
5. Explain giving three examples the importance of abrupt drug withdrawal in therapeutics.

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4 Answer any two of the following : 10

1. Discuss Vd, clearance and half life of a drug. Giving suitable examples explain their importance in clinical practise.
2. Discuss various drug-drug interactions in therapeutics giving suitable examples.
3. Enumerate various ß blockers. Discuss their uses giving the pharmacological basis for each use you mention.

R-1569] 2 [400]

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