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9203 2009 1_S43.doc
Rajiv Gandhi University of Health Sciences, Karnataka
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First Year M.Pharm Degree Examination – October 2010
[Time: 3 Hours] [Max. Marks: 100]
BULK DRUG TECHNOLOGY
(Revised Scheme 2)
Q.P. CODE : 9203
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Your answers should be specific to the questions asked.
Draw neat labeled diagrams wherever necessary. Answer all questions
LONG ESSAY (Answer any TWO) 2 X 20 = 40 Marks
- Organize a material balance sheet based upon chemical and equipment sequence for the manufacturing of niacinamide. Assume that only the pure readily available reactants are entering into the balance according to chemical reaction
- Explain the industrial production of phenytoin with respect to
- Reaction sequence and flow diagram
- Material of construction of equipments
- Purification procedure
- Possible effluents and its management
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- Design the equipments for the following
- molecular sieve-drying
- short path distillation
- continuous on-line filtration
- gas-liquid extraction
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SHORT ESSAY (Answer any FIVE) 5 X 10 = 50 Marks
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- Explain the concept, methodology, applications and limitations of cell culture method of drug production
- Write in detail the industrial production of Piperazine
- Explain the statutory requirement in establishing a 'repacking unit'
- What are the probable effluents from a plant manufacturing diclofenac? How will you deal with these effluents?
- What safety measures will you advise against 'atmospheric contamination' from your plant?
- Under what conditions are 'anti-dumping duties' levied for a bulk drug supplier
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SHORT NOTES 2 X 5 = 10 Marks
- Write the concept and method of formulation of Unani system of medicine
- Explain the applications of fermentation methods in bulk drug industry
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