Download RGUHS M.Pharmacy First Year May 2016 9347 Medicinal Chemistry ? I Drug Design Revised Scheme 4 Question Paper

Download RGUHS (Rajiv Gandhi University of Health Sciences) M Pharma (Master of Pharmacy) First Year (1st Year) May 2016 9347 Medicinal Chemistry ? I Drug Design Revised Scheme 4 Question Paper.

Rajiv Gandhi University of Health Sciences
First Year M. Pharm Degree Examination - May 2016
[Time: 3 Hours] [Max. Marks: 100]
Medicinal Chemistry ? I (Drug Design)
(Revised Scheme 4)
Q.P. CODE: 9347
Your answers should be specific to the questions asked.
Draw neat, labeled diagrams wherever necessary.

LONG ESSAY (Answer any TWO) 2 X 20 = 40 Marks
1. Explain various steps involved in developing a QSAR model and discuss the steric parameters
used in a QSAR.
2. a) Explain the rational design of non-covalent and covalent binding enzyme inhibitors.
b) Describe enzymes inhibitors as transition state analogs. (12+8)
3. Write notes on:
a) Conformational analysis
b) Virtual screening
c) Aromatase inhibitors
d) HIV-Protease inhibitor (5X4)

SHORT ESSAY (Answer any FIVE) 5 X 10 = 50 Marks
4. Discuss the design and development of prodrugs with two specific examples.
5. Explain the different non-covalent forces involved in drug receptor interaction.
6. Give an account of various protein-ligand docking techniques and their importance in drug
discovery.
7. Define the terms - receptor, agonist, partial agonist and antagonist. Discuss drug-receptor
interaction theories.
8. With suitable examples, explain the applications of recombinant DNA technology in pharmacy.
9. What is a lead molecule? Discuss the various stages involved in identification of a lead
molecule.

SHORT NOTES 2 X 5 = 10 Marks
10. Write a note on development of t-PA as a therapeutic agents.
11. What is epitope mapping? Give the importance of epitope mapping in drug design.

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