Rajiv Gandhi University of Health Sciences
First Year M. Pharm Degree Examination - May 2016
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[Time: 3 Hours] [Max. Marks: 100]
Medicinal Chemistry-II (Natural Products)
(Revised Scheme 4)
Q.P. CODE: 9348
Your answers should be specific to the questions asked.
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Draw neat, labeled diagrams wherever necessary.
LONG ESSAY (Answer any TWO) 2 X 20 = 40 Marks
- Elucidate the structure of reserpine.
- With suitable examples, describe the modifications carried out to obtain orally active penicillins and cephalosporins.
- Discuss the chemistry and biological importance of male and female sex hormones.
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SHORT ESSAY (Answer any FIVE) 5 X 10 = 50 Marks
- Give the structure and function of any two vinca alkaloids and elucidate the structure of any one of them.
- What are cardiac glycosides? Explain their chemistry and SAR.
- Explain the chemical features and mechanism of purine and pyramidine antimetabolites as Anti-neoplastic agents.
- Write the synthesis of an anti-fungal agent and an antipseudomonal penicillin.
- Write a note on microbial conversions as tool in the preparation of drugs.
- Write a note on chemistry of fat soluble vitamins.
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SHORT NOTES 2 X 5 = 10 Marks
- Write the synthesis of an antipseudomonal cephalosporin.
- Write the structures of Nocardicins with their therapeutic uses.
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