Rajiv Gandhi University of Health Sciences
First Year M.Pharm Degree Examination – Nov 2011
[Time: 3 Hours] [Max. Marks: 100]
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PHARMACOLOGICAL SCREENING METHODS AND CLINICAL EVALUATION
PAPER III
(RS 2 & RS 3)
Q.P. CODE: 9243
Your answers should be specific to the questions asked.
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Draw neat labeled diagrams wherever necessary. Answer all questions
LONG ESSAY (Answer any TWO) 2 X 20 = 40 Marks
- Briefly explain the CPCSEA guidelines for the usage of animal for research purpose
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- Write down the methods of indication of inflammation in experimental animals
- Freund's adjuvant - Explain
- Discuss in detail about evaluation of drugs for anti-inflammatory activity
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- Discuss in brief about discovery and development of new drugs
SHORT ESSAY (Answer any FIVE) 5 X 10 = 50 Marks
- Phase II metabolic reactions
- Patch - clamp technique
- Pharmacokinetic variability in individualization of drug therapy
- Screening of drugs for antiulcer activity
- Screening of drugs for epilepsy
- Screening of drugs for amnesia
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SHORT NOTES 2 X 5 = 10 Marks
- Four point bioassay
- Transgenic and knockout animals
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